- Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Randomized Study of Andexanet Alfa Compared to Usual Care in Patients Receiving a Factor Xa Inhibitor who Require Urgent Surgery or Procedure (ANNEXA-RS)
This study is comparing a new medication called Andexanet Alfa to usual care. It's for patients who are taking blood thinners (like apixaban, rivaroxaban, or edoxaban) and need urgent surgery. The aim is to see if Andexanet Alfa helps stop bleeding during their operation.
For: Reversal of anticoagulation effect in patients on a FXa inhibitor (apixaban · rivaroxaban · or edoxaban) who require urgent surgery or procedureFrance · Portugal · Spain - Ongoing, recruitingTherapeutic use (Phase IV)
Randomized trial on Spinal Anaesthesia vs. General Anaesthesia (SAGA) on recovery after total hip, total knee, and unicompartmental knee arthroplasty
This study compares two types of anaesthesia—spinal and general—for hip and knee replacement surgeries. It aims to see which one helps patients get back on their feet faster, specifically if they can walk 5 metres within 6 hours after surgery.
For: Osteoarthritis of the hip and kneeDenmark - Ongoing, recruitingTherapeutic confirmatory (Phase III)
AcTIVE - ACid tranexamic or Terlipressin for Initial emergency treatment of mild to seVere hEmoptysis: a randomized Trial
This study is looking at new ways to treat people who cough up blood, called hemoptysis. Researchers are testing two medicines, tranexamic acid and terlipressin, against a salt water solution to see which one works best to stop the bleeding and help patients recover without needing other procedures.
For: Hemoptysis · whatever the cause · with the exception of cystic fibrosisFrance