Trifluridine/tipiracil clinical trials
7 indexed studies · 4 currently recruiting
- RecruitingPHASE2
- IKF/AIO-QUINTIS - Evaluating Fruquintinib in Combination With Tislelizumab in Microsatellite Stable / Proficient Mismatch Repair (MSS/pMMR) Metastatic Colorectal Cancer Without Active Liver Metastases
This study is testing two new drug combinations for advanced bowel cancer that has spread, but not actively to the liver. It aims to see if a new combination of two medicines, Fruquintinib and Tislelizumab, works better than standard treatment for this type of cancer.
For: Metastatic Colorectal CancerAustria · Germany - Active not recruitingPHASE3
A Study to Evaluate Sacituzumab Tirumotecan (MK-2870) in Advanced/Metastatic Gastroesophageal Adenocarcinoma (MK-2870-015)
This study looks at a new medicine, sacituzumab tirumotecan, for advanced stomach or oesophagus cancer. It compares this new medicine to standard treatments to see if it's safer and works better for patients who have already had other treatments.
For: Gastroesophageal CancerUnited States · Belgium · Brazil - Active not recruitingPHASE1, PHASE2
A Study in Advanced or Metastatic Gastrointestinal Cancers Exploring Treatment Combinations With Pelareorep and Atezolizumab
This study is testing new combinations of drugs for advanced stomach and bowel cancers, including anal and pancreatic cancers. We want to see if these treatments are safe and if they help shrink tumors or stop them from growing. It involves several groups, some trying new drug combinations.
For: Anal Cancer Metastatic · Squamous Cell Carcinoma of the Anus Stage Unspecified · Pancreatic Cancer MetastaticGermany - RecruitingPHASE1, PHASE2
A Trial to Find Out How Safe REGN7075 is and How Well it Works in Combination With Cemiplimab for Adult Participants With Advanced Cancers
This study looks at a new drug, Marlotamig, by itself and with other treatments for advanced cancers. We want to see if it's safe, how well it works, and find the best dose to help shrink tumours.
For: Advanced Solid TumorsUnited States · France · Israel - RecruitingPHASE1
Phase 1 Study of INBRX-109 in Subjects With Locally Advanced or Metastatic Solid Tumors Including Sarcomas
This early-stage study is testing a new drug, INBRX-109, for people with advanced solid tumours, including certain types of Ewing sarcoma and bowel cancer. Researchers want to see if it's safe and how well it works, both alone and with standard treatments. This is for patients who haven't responded to previous therapies.
For: Ewing Sarcoma · Colorectal AdenocarcinomaUnited States · France · Italy - Active not recruitingPHASE1
Study to Assess Adverse Events and Change in Disease Activity in Adult Participants With Advanced Solid Tumors Receiving Intravenous (IV) ABBV-400 as Monotherapy and in Combination With IV Bevacizumab
This study looks at a new drug, ABBV-400, for advanced cancers like lung and bowel cancer. We're checking how safe it is and if it helps shrink tumours, both on its own and with another drug.
For: Non-Small Cell Lung Cancer · Advanced Solid Tumors · Gastroesophageal AdenocarcinomaUnited States · Australia · France - RecruitingPHASE3
Trifluridine/Tipiracil + Fruquintinib Versus Trifluridine/Tipiracil Alone for Metastatic Oeso-gastric Adenocarcinoma
This study looks at a new combination of medicines for advanced stomach or oesophagus cancer. It compares giving two drugs, trifluridine/tipiracil and fruquintinib, together, against giving trifluridine/tipiracil alone, to see if the combination works better.
For: Metastatic Oesogastric AdenocarcinomaFrance · Germany