- Enrolling by invitationPHASE1
TSPO Endothelial - EMPATHY
This study looks at how a drug called XBD173 affects blood vessel cells in people with a lung condition called Pulmonary Arterial Hypertension (PAH). Researchers want to see if targeting a protein in these cells can help understand and treat PAH, where blood vessels in the lungs narrow and make the heart work harder.
For: PAHUnited Kingdom - Enrolling by invitationPHASE2
TSPO Modulation in AD
This study looks at a new drug, XBD173, for Alzheimer’s disease. It wants to see if the drug can improve how blood flows to the brain, which is important for brain health and memory. The drug is taken for 28 days.
For: Alzheimer s DiseaseUnited Kingdom - RecruitingNA
Validation of the 18 kiloDalton Translocator Protein (TSPO) as a Novel Neuroimmunodulatory Target
This study looks at new ways to treat multiple sclerosis (MS) by targeting a protein called TSPO. We're testing two drugs, XBD173 and Etifoxine, to see if they can reduce harmful immune activity in people with secondary progressive MS and in healthy volunteers.
For: Multiple SclerosisUnited Kingdom - RecruitingNA
Targeting 18kDa Translocator Protein (TSPO) to Improve Brain Endothelial Cell Function in Cerebral Small Vessel Disease
This study looks at a new drug, XBD173, for Cerebral Small Vessel Disease (cSVD). We want to see if it can improve how blood vessels in the brain work and get enough blood where it's needed, by affecting a protein called TSPO.
For: Cerebral Small Vessel DiseaseUnited Kingdom - Enrolling by invitationNA
TSPO Occupancy in the Human Lung
This study looks at how a new drug, XBD173, affects the lungs in healthy people. We want to find out how much of the drug is needed in the body to make a specific protein, TSPO, active in the lungs, and if food changes this.
For: Healthy Volunteers - Male and FemaleUnited Kingdom - RecruitingPHASE2
Role of a Mitochondrial Receptor in Blood Sugar Regulation
This study looks at a new medicine called XBD173. We want to see how a single dose changes blood sugar levels in healthy people. This helps us understand how the body handles sugar, which could be important for future health treatments.
For: Heathly VolunteersUnited Kingdom