- Ongoing, recruitingTherapeutic exploratory (Phase II)
An International, Phase 2, Open-Label, Randomized Study of BGB-3111 Combined With Obinutuzumab Compared With Obinutuzumab Monotherapy in Relapsed/ Refractory Follicular Lymphoma
This study looks at a new drug, zanubrutinib, combined with obinutuzumab, for people with follicular lymphoma that has come back or not responded to previous treatment. It compares this combination with obinutuzumab alone, to see if the new combination works better.
For: Relapsed/Refractory Follicular LymphomaFrance · Czechia · Italy - Active not recruitingPHASE3
A Study Comparing Zanubrutinib With Bendamustine Plus Rituximab in Participants With Previously Untreated CLL or SLL
This study compares a new drug, zanubrutinib, with standard treatments (bendamustine and rituximab) for adults with previously untreated Chronic Lymphocytic Leukaemia (CLL) or Small Lymphocytic Lymphoma (SLL). Researchers want to see which treatment works best to stop the cancer from getting worse.
For: Chronic Lymphocytic Leukemia · Small Lymphocytic LymphomaUnited States · Australia · Austria - RecruitingPHASE3
A Study to Investigate Sonrotoclax (BGB-11417) Plus Zanubrutinib (BGB-3111) Compared With Venetoclax Plus Acalabrutinib in Adults With Previously Untreated Chronic Lymphocytic Leukemia
This study is looking at two new drug combinations for adults newly diagnosed with Chronic Lymphocytic Leukemia (CLL). It compares sonrotoclax plus zanubrutinib with venetoclax plus acalabrutinib to see which is more effective and safer for treating this type of blood cancer.
For: Chronic Lymphocytic LeukemiaUnited States · Australia · Brazil - RecruitingPHASE3
A Study of Zanubrutinib Plus Anti-CD20 Versus Lenalidomide Plus Rituximab in Participants With Relapsed/Refractory Follicular or Marginal Zone Lymphoma
This study is testing new treatments for two types of lymphoma, follicular and marginal zone lymphoma, when they have come back or not responded to previous treatment. It compares a drug called zanubrutinib combined with other medicines against a standard treatment to see which works best.
For: Relapsed/Refractory Follicular Lymphoma · Marginal Zone LymphomaUnited States · Argentina · Australia - Active not recruitingPHASE2, PHASE3
A Study to Examine the Efficacy and Safety of Zanubrutinib Given to Adults With Primary Membranous Nephropathy
This study is testing a new medicine called zanubrutinib for people with a kidney condition called primary membranous nephropathy. It compares zanubrutinib with a standard medicine, tacrolimus, to see how well it reduces protein in the urine and helps people get better.
For: Primary Membranous NephropathyUnited States · Brazil · Canada - Active not recruitingPHASE3
Comparison Between Rituximab Plus Zanubrutinib Versus Rituximab Monotherapy in Untreated SMZL Patients
This study compares two treatments for a type of slow-growing lymphoma called Splenic Marginal Zone Lymphoma (SMZL). It looks at whether a combination of two drugs, rituximab and zanubrutinib, works better and is as safe as rituximab alone for patients needing their first treatment.
For: Splenic Marginal Zone LymphomaAustria · France · Italy - RecruitingPHASE3
A Study to Investigate the Efficacy and Safety of Sonrotoclax Plus Zanubrutinib Compared With Placebo Plus Zanubrutinib in Adults With Relapsed/Refractory Mantle Cell Lymphoma (CELESTIAL-RRMCL)
This study is looking at a new combination of medicines, sonrotoclax plus zanubrutinib, for adults in the UK with a type of blood cancer called Mantle Cell Lymphoma. It aims to see if this combination works better and is safe when their cancer has come back or isn't responding to other treatments.
For: Mantle Cell Lymphoma · B Cell LymphomaUnited States · Argentina · Australia - Active not recruitingPHASE1, PHASE2
A Study to Investigate the Safety of Novel Dose Ramp-up Schedule(s) When Initiating Sonrotoclax in Participants Treated for Blood Cancers.
This study looks at new ways to give a medicine called sonrotoclax for blood cancers like Chronic Lymphocytic Leukemia (CLL). We want to find the safest and most effective starting dose schedule, often with another medicine called zanubrutinib, to help patients.
For: Chronic Lymphocytic Leukemia · CLLUnited States · Australia · France - Active not recruitingPHASE3
Study of BTK Inhibitor LOXO-305 Versus Approved BTK Inhibitor Drugs in Patients With Mantle Cell Lymphoma (MCL)
This study compares a new drug, pirtobrutinib, with existing approved treatments for people with a type of blood cancer called mantle cell lymphoma (MCL). It's for patients who have already had at least one treatment and are looking for other options.
For: Lymphoma, Mantle-CellUnited States · Australia · Austria - Active not recruitingPHASE3
Study of Sonrotoclax (BGB-11417) Plus Zanubrutinib (BGB-3111) Compared With Venetoclax Plus Obinutuzumab in Participants With Chronic Lymphocytic Leukemia (CLL)
This study compares two treatments for chronic lymphocytic leukaemia (CLL), a type of blood cancer. We're looking at whether a new combination (sonrotoclax with zanubrutinib) works better than a standard one (venetoclax with obinutuzumab) in people who haven't had treatment before.
For: CLLUnited States · Australia · Austria - Active not recruitingPHASE3
A Study to Investigate the Efficacy of Zanubrutinib Plus Rituximab Compared With Bendamustine Plus Rituximab in Adults With Previously Untreated Mantle Cell Lymphoma Who Are Ineligible for Stem Cell Transplantation
This study looks at new treatments for Mantle Cell Lymphoma in adults who can't have a stem cell transplant. It compares two drug combinations to see which works better and is safer.
For: Mantle Cell Lymphoma; Non-Hodgkin LymphomaUnited States · Australia · Austria - Active not recruitingPHASE1
Study of Bcl-2 Inhibitor Sonrotoclax (BGB-11417) in Participants With Mature B-Cell Malignancies
This study is testing a new medicine called sonrotoclax for certain blood cancers like lymphoma and leukaemia. We want to find the safest and most effective dose, both on its own and when combined with other medicines, to help patients with these conditions.
For: Mature B-Cell MalignanciesUnited States · Australia · Germany - RecruitingPHASE2
Zanubrutinib Plus Rituximab for Patients With Indolent Mantle Cell Lymphoma
This study is looking at a new treatment approach for a type of slow-growing (indolent) mantle cell lymphoma. It compares observing the condition with a combination of two drugs, zanubrutinib and rituximab, given for a set period, to see if earlier treatment is helpful.
For: Mantle Cell LymphomaUnited Kingdom - Active not recruitingPHASE3
Long-term Extension Study of Zanubrutinib (BGB-3111) Regimens in Participants With B-cell Malignancies
This study looks at the long-term safety of a drug called zanubrutinib for people with certain blood cancers (B-cell malignancies). It's for those who have already taken zanubrutinib in a previous study.
For: B-cell MalignanciesUnited States · Australia · China - Active not recruitingPHASE2
A Study to Investigate Efficacy and Safety of BCL2 Inhibitor Sonrotoclax as Monotherapy and in Combination With Zanubrutinib in Adults With Waldenström Macroglobulinemia
This study looks at a new drug, Sonrotoclax, for adults with Waldenström Macroglobulinemia. It tests the drug alone for those whose previous treatments weren't enough, and with another drug, Zanubrutinib, for those who haven't had treatment before. The aim is to see if it's safe and effective.
For: Waldenstrom Macroglobulinemia · Waldenstrom's Macroglobulinemia Recurrent · Waldenstrom's Macroglobulinemia RefractoryUnited States · Australia · Canada