- RecruitingPHASE1, PHASE2
Substudy 03C: A Study of Combination Therapies in Participants With Renal Cell Carcinoma With Recurrent Disease During or After Anti-PD-(L)1 Therapy (MK-3475-03C/KEYMAKER-U03)
This study looks at new drug combinations for kidney cancer (renal cell carcinoma) that has come back after previous treatment. It aims to find out if these combinations are safe and effective. It's for people aged 18-120 with this specific type of kidney cancer.
For: Renal Cell CarcinomaUnited States · Chile · France - Active not recruitingPHASE2, PHASE3
Study of Zanzalintinib (XL092) + Pembrolizumab vs Pembrolizumab in Subjects With PD-L1 Positive Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
This study is for people with head and neck cancer that has come back or spread and can't be cured by usual treatments. It compares a new drug, zanzalintinib, combined with pembrolizumab, against pembrolizumab alone, to see if the new combination works better.
For: Head and Neck Squamous Cell CarcinomaUnited States · Argentina · Australia - RecruitingPHASE2, PHASE3
Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors
This study compares two medicines, zanzalintinib and everolimus, for treating advanced neuroendocrine tumours. It aims to see which is more effective for people whose tumours have grown or spread despite previous treatments. This is a crucial step in finding better ways to manage this condition.
For: Pancreatic Neuroendocrine Tumor (pNET) · Extra-Pancreatic Neuroendocrine Tumor (epNET)United States · Australia · Austria - RecruitingPHASE1
Study of Zanzalintinib in Combination With Immuno-Oncology Agents in Participants With Solid Tumors
This study is testing a new drug, zanzalintinib, alone and with other medicines, for people with advanced cancers like kidney, prostate, and lung cancer. It's looking at safety and if the treatment shrinks tumours.
For: Renal Cell Carcinoma (RCC) · Metastatic Castration-Resistant Prostate Cancer (mCRPC) · Urothelial Carcinoma (UC)United States · Australia · Austria