Active not recruitingNAINTERVENTIONAL

Emergency Department Triage of Patients With Acute Chest Pain Based on the ESC 0/1-hour Algorithm (PRESC1SE-MI)

The PRESC1SE-MI study is looking at two different methods used in emergency departments to figure out if someone with sudden chest pain is having a heart attack. Both methods involve taking blood samples to measure a heart-specific substance called troponin, which goes up when the heart muscle is damaged. The current standard method takes a blood sample when you arrive and again after 3 hours. This study is comparing it to a newer method that takes a sample when you arrive and again after just 1 hour. Doctors want to see if this faster, 1-hour method is just as accurate and safe as the 3-hour method for diagnosing heart attacks.

At a glance

Status

Active not recruiting

Phase

Sponsor

University Hospital, Basel, Switzerland

Enrolment target

64,374

Start

01 Dec 2020

Estimated completion

31 May 2028

Acute Chest Pain NSTEMI - Non-ST Segment Elevation MI

What is this study about?

Imagine you go to A&E with sudden chest pain – it can be a worrying time, and doctors need to quickly work out what's causing it. One of the main concerns is a heart attack. This study, called PRESC1SE-MI, is all about making that process faster and just as safe.

Our hearts release a special marker called troponin when they are damaged, for example, during a heart attack. Doctors check for this marker in your blood. Currently, most hospitals use a method where they take a blood sample when you first arrive and then another one 3 hours later. This study is comparing this 3-hour check to a newer, quicker 1-hour check. This faster method involves taking a blood sample when you arrive and again just 1 hour later.

The main goal of this study is to see if this quicker 1-hour blood test method is just as good and reliable at finding heart attacks as the current 3-hour method. It's about finding out if we can save precious time in diagnosing and treating heart attacks without compromising safety or accuracy. If the 1-hour method proves to be as effective, it could help doctors make decisions faster and potentially improve patient care.

Key takeaways

Compares two ways to diagnose heart attacks quickly in A&E.
Looks at if a 1-hour blood test is as good as a 3-hour test.
Could help doctors make faster decisions for chest pain.
Focuses on improving diagnosis without changing treatment.
Aims to make emergency care more efficient and just as safe.

Who may be eligible?

This study is looking for adults aged 18 or older who come to A&E with new, sudden chest pain that isn't caused by an injury. Doctors would be considering if your chest pain could be a sign of a heart attack.

You would not be able to join the study if you have severe kidney failure that requires dialysis, or if you've recently had a cardiac arrest (where your heart stops beating) or cardiogenic shock (a serious condition where your heart can't pump enough blood).

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Are you in A&E because of new, sudden chest pain not due to an injury?
Are doctors considering if your chest pain could be a heart attack?
Do you NOT have severe kidney failure requiring dialysis?
Have you NOT recently had a cardiac arrest or cardiogenic shock?

Answer every question to see your result.

What does participation involve?

This study focuses on how quickly blood tests are taken to help diagnose chest pain. If you take part, your doctor will follow one of two different schedules for taking your blood samples to check for heart-related markers. One schedule involves taking blood when you arrive and again after 3 hours, and the other takes blood when you arrive and again after 1 hour. The specific schedule your doctor might use would be decided by the study. Otherwise, you would receive the usual care you would expect for chest pain in A&E. There are no extra visits or medications involved specifically for this study beyond what the doctors would normally do to treat you. The duration of your participation would be for the time you are in the emergency department for this particular episode of chest pain.

Potential risks and benefits

Taking part in this study may or may not directly benefit you, but the information gained could help improve how doctors quickly diagnose heart conditions for future patients. The main procedures, like taking blood samples, are standard practice when you visit A&E with chest pain. While there are minimal risks involved, such as slight bruising or discomfort from blood tests, these are generally very minor. Your doctors will continue to provide you with the best medical care throughout. Remember, you can always decide not to participate or withdraw from the study at any time without affecting your medical treatment.

Locations (20)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

Baylor St. Luke's Medical Center
Verified postcode
Houston, United States
St Andrew's War Memorial Hospital Brisbane
Verified postcode
Brisbane, Australia
Vienna General Hospital (AKH Wien)
Verified postcode
Vienna, Austria
University Central Hospital Helsinki
Verified postcode
Helsinki, Finland
Attikon General Hospital Athens
Verified postcode
Athens, Greece
Careggi University Hospital Florence
Verified postcode
Florence, Italy
Azienda Ospedaliera San Giovanni Addolorata
Verified postcode
Roma, Italy
Hospital Città della Salute e della Scienza di Torino
Verified postcode
Torino, Italy
Emergency Institute for Cardiovascular Diseases C.C. Iliescu
Verified postcode
Bucharest, Romania
Konkuk University Medical Center
Verified postcode
Seoul, South Korea
Hospital Clinic Barcelona
Verified postcode
Barcelona, Spain
University Hospital October 12 Madrid
Verified postcode
Madrid, Spain

Common questions

What is troponin?

Troponin is a substance released into your blood when your heart muscle is damaged, like during a heart attack. Doctors measure it to see if there's heart damage.

What's the difference between the 0/1-hour and 0/3-hour tests?

Both involve taking a blood sample when you arrive. The 0/1-hour test takes a second sample after 1 hour, while the 0/3-hour test takes the second sample after 3 hours.

Will taking part change my medical treatment?

No, your doctors will still provide you with the best possible care for your chest pain, whether or not you're part of the study. The study looks at the timing of blood tests.

Is the study safe?

Yes, this study is about comparing standard diagnostic approaches already used in hospitals. The procedures are routine, and your safety is the priority.

Why is this study important?

It could help doctors find heart attacks faster. If the 1-hour test is just as accurate, it could lead to quicker decisions and better care for people with chest pain.