Ongoing, recruitingTherapeutic use (Phase IV)Interventional

A randomized trial on Hemodynamic Optimization of cerebral Perfusion after Endovascular therapy in patients with acute ischemic stroke (HOPE study)

This study, called the HOPE study, is investigating how different blood pressure medications might help people recover after experiencing a type of stroke called an ischemic stroke. This happens when a blood clot blocks blood flow to the brain, and patients have received a special treatment to remove the clot. The researchers are comparing different medicines (Urapidil, Labetalol, or Phenylephrine) to see which one is most effective at keeping blood flow to the brain at a healthy level. They will look at patients' recovery 90 days after treatment, specifically focusing on how well they can do daily activities. The aim is to find the best way to support the brain after a stroke and its treatment.

At a glance

Status

Ongoing, recruiting

Phase

Therapeutic use (Phase IV)

Sponsor

Fundacio Institut De Recerca De L'Hospital De La Santa Creu I Sant Pau

Enrolment target

814

Start

11 Nov 2024

Acute Ischemic Stroke

What is this study about?

Imagine your brain is a garden. When you have a type of stroke called an ischemic stroke, it's like a water pipe gets blocked, and parts of your garden don't get enough water. Doctors can sometimes clear this blockage using a treatment called endovascular therapy, which is like unclogging the pipe.

After the pipe is clear, it's very important to make sure the right amount of water (blood) flows to the garden. Too much pressure can burst the delicate plants, and too little water won't help them recover. This study, called the HOPE study, is focused on finding the best way to manage blood pressure right after stroke treatment to make sure your brain gets the perfect amount of blood flow to help it heal.

Researchers are comparing three different medicines that can help control blood pressure. They want to see which one leads to the best recovery for patients three months after their stroke. By finding the best way to manage blood pressure, doctors can improve the chances of a good recovery for future stroke patients.

Key takeaways

Study compares blood pressure medicines after stroke treatment.
Aims to find the best way to help the brain heal.
Looks at recovery 90 days after stroke.
All adults (18+) who've had a specific stroke treatment can participate.
Results could improve future stroke care.

Who may be eligible?

To be able to take part in this study, you would need to be an adult, 18 years old or older. There is no upper age limit, meaning older adults can also participate.

Both men and women are welcome to join this study. The researchers want to understand how these treatments work for everyone who experiences an acute ischemic stroke and has received specific emergency treatment to unblock a blood vessel in their brain.

Beyond these general points, doctors and nurses involved in the study would check other medical details to make sure the study is right and safe for you, as specific stroke characteristics and other health conditions are important.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Have you recently had an ischemic stroke?
Have you received treatment to unblock a blood vessel in your brain?
Are you able to provide consent for yourself or with help from a legal representative?

Answer every question to see your result.

What does participation involve?

If you are eligible and choose to take part in the HOPE study, you would receive one of three different blood pressure medicines, chosen by chance (like flipping a coin). This is part of the standard care you would get after your stroke treatment.

During your time in the hospital, doctors and nurses would carefully monitor your blood pressure and overall health. They will collect information about your recovery, just like they normally would after a stroke.

After you leave the hospital, the main follow-up will be around 90 days (about three months) after your stroke. A healthcare professional will check in with you to understand how well you are recovering and how you are managing daily activities. There are no extra hospital visits specifically for this study beyond your usual stroke care and the 90-day check-up.

Potential risks and benefits

Taking part in this study means you'll receive one of the standard blood pressure treatments used after a stroke, aiming to find the most effective approach for brain recovery. There's a chance that the specific medicine you receive might lead to a better recovery, but like all medicines, there could be side effects, which your doctors will monitor closely. You have the right to withdraw from the study at any time, for any reason, without it affecting your medical care.

Locations (1)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

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Unverified
Spain

Common questions

What is an 'ischemic stroke'?

An ischemic stroke happens when a blood clot blocks blood flow to part of your brain, similar to a pipe getting clogged.

What does 'endovascular therapy' mean?

This is a treatment where doctors use special tools to remove the blood clot from inside a brain blood vessel.

Why is blood pressure important after a stroke?

Managing blood pressure carefully after a stroke and treatment helps make sure your brain gets the right amount of blood flow to recover well.

Will I know which medicine I'm getting?

Yes, your doctors will know which blood pressure medicine you are receiving as part of your treatment plan.

How long will I be involved in the study?

Your main involvement in terms of follow-up will be a check-up around 90 days (three months) after your stroke.