A Study of the Efficacy and Safety of Adjuvant Autogene Cevumeran Plus Atezolizumab and mFOLFIRINOX Versus mFOLFIRINOX Alone in Participants With Resected PDAC

This study is looking for adults aged 18 or older who have recently had surgery for pancreatic cancer. Specifically, your doctor must have confirmed that all visible cancer was removed during the operation, and tests show no remaining signs of the disease afterwards. You also cannot have received any previous treatment for your pancreatic cancer, like chemotherapy, before joining this study.

To be considered, you'll need to have had your surgery between 6 and 12 weeks before starting the study treatment, and you must have recovered well enough from the operation to receive further treatments. Your body also needs to be in good working order, with healthy blood counts and organ function.

There are also some reasons why you might not be able to join. For example, if you've already had any anti-cancer treatment for your pancreatic cancer, or if you had your spleen removed during your pancreatic surgery. Also, if you have a certain nerve condition (neuropathy) or a specific genetic condition affecting how your body handles some drugs, you wouldn't be able to participate. Women must agree to avoid pregnancy during and for some time after the study, and men must use contraception if their partner could become pregnant.

If you decide to take part in this study, you will be assigned to one of two treatment groups: either the new combination of treatments (Autogene Cevumeran, Atezolizumab, and mFOLFIRINOX) or the standard mFOLFIRINOX treatment alone. You will receive these treatments over a period of time, usually given through a drip at a clinic.

You will have regular appointments and tests throughout the study. These will include blood tests to check your general health and levels of a specific marker (CA19-9), and scans to ensure the cancer has not returned. There will also be check-ups to monitor how you are feeling and to record any side effects you might experience. After your main treatment period finishes, you will continue to have follow-up appointments and checks to see how you are doing in the long term. The total duration of your participation, including follow-up, will be determined by the study plan, but some follow-up might continue for several years.