Not yet recruitingNAINTERVENTIONAL

Remote Ischemic Postconditioning in Septic Shock

This study is looking into a new treatment called remote ischemic postconditioning (RIPOST) for adults in intensive care with septic shock. Septic shock is a serious condition where the body's reaction to an infection causes very low blood pressure and organ damage. Sadly, many people die from it. RIPOST is a straightforward method that involves repeatedly inflating and deflating a blood pressure cuff on a patient's arm for short periods. This may help protect the body's organs. It's already been tested successfully in other heart conditions and strokes. This study aims to see if this easy, affordable technique can help improve the chances of survival for patients with septic shock. We believe it could significantly improve their outcomes.

At a glance

Status

Not yet recruiting

Phase

Sponsor

Hospices Civils de Lyon

Enrolment target

720

Start

01 Apr 2026

Estimated completion

01 Jul 2028

Adult Patients With Septic Shock Admitted in Intensive Care Unit

What is this study about?

Septic shock is a very serious and life-threatening condition. It happens when your body has an extreme reaction to an infection, causing your blood pressure to drop dangerously low and your organs to stop working properly. Despite a lot of research, it's still a major cause of death worldwide, and we have very few treatments that are truly effective in helping people recover.

This study is exploring a new treatment called Remote Ischemic Postconditioning, or RIPOST. It's a simple, non-invasive (meaning it doesn't involve surgery or needles) technique. It works by repeatedly inflating and deflating a blood pressure cuff on your arm, similar to how your blood pressure is measured, but for several short bursts. This process might help protect your body's organs from further damage caused by septic shock.

RIPOST has shown promise in other health problems, like heart attacks and strokes, where it has been found to be safe and potentially effective in improving patients' recovery and even long-term survival. Animal studies and small human studies have also hinted that RIPOST could be helpful for people with sepsis and septic shock. This study aims to find out if this easy-to-use, inexpensive, and readily available method can genuinely improve the chances of survival for adults battling septic shock.

Key takeaways

Septic shock is a very serious condition.
This study explores a potential new treatment called RIPOST.
RIPOST involves short, repeated inflation/deflation of a blood pressure cuff on the arm.
The treatment is non-invasive and relatively inexpensive.
The main goal is to see if RIPOST can improve survival for patients.
Participation would be for adults in intensive care with septic shock.

Who may be eligible?

To be part of this study, you need to be an adult (18 years or older) who has been admitted to intensive care recently (within 24 hours). You must also have been diagnosed with septic shock that started less than 18 hours ago.

We would need your agreement, or the agreement of a close family member, to take part. In emergency situations, local rules might allow for starting the treatment quickly, with full consent discussed as soon as possible afterwards.

There are some reasons why you couldn't join. For example, if you can't have a blood pressure cuff used on both arms, have had a recent heart attack where your heart stopped, are pregnant or breastfeeding, or are already taking part in another clinical study. Also, if you don't have French national health insurance or have certain legal protections in place, you wouldn't be able to participate. This study is open to both men and women.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Have you been admitted to intensive care recently (less than 24 hours ago)?
Have you been diagnosed with septic shock that started less than 18 hours ago?
Are you able to use a blood pressure cuff on both arms?
Are you not pregnant or breastfeeding?
Are you not currently part of another medical study?

Answer every question to see your result.

What does participation involve?

If you or your loved one takes part in this study, you would receive the RIPOST treatment. This involves wearing a standard blood pressure cuff on one of your arms. The cuff will be inflated and deflated several times over a short period. This is a non-invasive procedure, similar to having your blood pressure checked. Other than receiving this specific treatment, there are no additional visits, assessments, or medications beyond the standard care you would already be receiving in the intensive care unit. The total duration of the study's intervention would be completed within a short time frame while you are in the intensive care unit, and researchers would then monitor your progress as part of your ongoing medical care.

Potential risks and benefits

The potential benefit of participating in this study is that the RIPOST treatment might improve your chances of survival from septic shock. While RIPOST has been shown to be safe in other conditions, like heart attacks, there's always a possibility of minor discomfort or bruising from the blood pressure cuff. This treatment is non-invasive and does not involve any new medicines or surgery. Please remember that you or your loved one has the right to withdraw from the study at any time, for any reason, without it affecting your medical care.

Locations (23)

Service de Réanimation Médicale, Hôpital Jean-Minjoz, CHU de Besançon
Verified postcode
Besançon, France
Service Réanimation Polyvalente, Centre Hospitalier de Fleyriat
Verified postcode
Bourg-en-Bresse, France
Service de Médecine Intensive- Réanimation, Hôpital Gabriel Montpied, CHU de Clermont-Ferrand
Verified postcode
Clermont-Ferrand, France
Service de Médecine Intensive-Réanimation, Hôpital Henri Mondor, Assistance Publique des Hôpitaux de Paris
Verified postcode
Créteil, France
Service de Médecine intensive-Réanimation,Hôpital F Mitterrand, CHU de Dijon
Verified postcode
Dijon, France
Service de Médecine intensive-Réanimation,Hôpital Albert Michallon, CHU de Grenoble
Verified postcode
La Tronche, France
Service de Médecine Intensive-Réanimation, Hôpital Bicêtre, Assistance Publique des Hôpitaux de Paris
Verified postcode
Le Kremlin-Bicêtre, France
Service de Médecine Intensive-Réanimation, Hôpital Salengro, CHU de Lille
Verified postcode
Lille, France
Service de Médecine Intensive-Réanimation, Hôpital Edouard Herriot, Hospices Civils de Lyon
Verified postcode
Lyon, France
Service Réanimation Polyvalente, Hôpital Saint-Joseph Saint-Luc
Verified postcode
Lyon, France
Service de Médecine Intensive-Réanimation, Hôpital Nord, Assistance Publique des Hôpitaux de Marseille
Verified postcode
Marseille, France
Service de Réanimation des Urgences, Hôpital de la Timone, CHU de Marseille
Verified postcode
Marseille, France

Common questions

What is septic shock?

Septic shock is a life-threatening condition where your body's extreme reaction to an infection causes very low blood pressure and organs to start failing.

What is RIPOST?

RIPOST (Remote Ischemic Postconditioning) is a simple treatment using a blood pressure cuff on your arm, inflated and deflated repeatedly, to try and protect your organs.

Is RIPOST safe?

Studies in other conditions like heart attacks suggest RIPOST is safe. This study is looking at its safety and effectiveness specifically for septic shock.

Will I get this treatment if I don't join the study?

RIPOST is not standard care for septic shock yet. You would only receive this specific treatment if you participate in the study.

Who is running this study?

This study is being conducted by researchers aiming to find new ways to improve care for patients with septic shock.

How to find out more

Martin COUR, MD

martin.cour@chu-lyon.fr 4 72 11 28 52 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.