ChariotMS - Cladribine to Halt Deterioration in People With Advanced Multiple Sclerosis

To join this study, you would need to be an adult (18 years or older) with advanced MS where you need some help with walking, possibly using a stick for short distances, or even a wheelchair for longer distances. We'd also check that your arm and hand movements meet certain levels, as this is important for how we measure the drug's effects. You would need to have had regular health screenings recommended by the NHS, such as for bowel or breast cancer.

However, there are reasons why you might not be able to join. For example, if you have severe kidney or liver problems, uncontrolled diabetes or high blood pressure, or a history of heart attack or stroke, you probably wouldn't be suitable. If you are pregnant, planning to become pregnant, or breastfeeding, you also couldn't take part. We can make exceptions for some past serious illnesses like cancer if your treatment team confirms you are clear.

If you decide to take part in this study, you'll be assigned to either receive the study drug (Cladribine) or a placebo (a dummy treatment, like a sugar pill). You won't know which one you're getting, and neither will your study doctor. The treatment will be given in short courses over two years. This means you'll take tablets for about 8-10 days each year.

You'll have regular visits to the study clinic for check-ups, blood tests, and to assess your MS symptoms and abilities, like how you use your hands. Researchers will also be looking at the cost-effectiveness of the treatment. These visits will help us understand how the treatment is working and monitor your health carefully. The total study duration will be several years, including follow-up after your treatment courses.