AuthorisedTherapeutic exploratory (Phase II)Interventional

TAILOR-PANC: Molecularly Tailored Therapy versus Standard Care in Advanced Pancreatic Cancer (DPCG-02)

This study, called TAILOR-PANC, is for people with advanced pancreatic cancer. It's investigating whether 'molecularly tailored' treatments – which means choosing medicines based on the specific features of an individual's cancer – can be more effective than standard treatments. Researchers want to see if these tailored therapies can slow down cancer growth for a longer time. They will also look at how long people live, how much the cancer shrinks, and how patients feel in terms of their overall health and quality of life. This is a Phase II study, which means it's testing whether these new approaches work well and are safe. Participants can be aged 18 or over, male or female. The goal is to find better ways to treat this type of cancer.

At a glance

Status

Authorised

Phase

Therapeutic exploratory (Phase II)

Sponsor

Region Hovedstaden

Enrolment target

1,200

Start

18 May 2026

Advanced pancreatic cancer

What is this study about?

Imagine your cancer is like a lock, and the medicines are like keys. With 'standard' treatment, everyone gets the same set of master keys hoping one will fit. But in this study, researchers are trying a different approach. They're looking closely at each person's specific cancer cells, trying to understand their unique features – like looking at the tricky details of your personal lock.

Once they understand those details, they can pick a 'tailored' medicine (or a specific key) that is more likely to work for *your* particular cancer. This study wants to find out if this personalised approach, where treatment is matched to your cancer's unique characteristics, can stop the cancer from growing for longer. It's hoped that this might work better than the standard treatments currently used.

The main thing the study will measure is how long people live without their cancer getting worse. They will also check other important things like how long people live overall, whether the cancer shrinks, and how the different treatments affect people's quality of life – how they feel physically and emotionally.

Key takeaways

This study explores personalised treatments for advanced pancreatic cancer.
It compares tailored therapies with standard care.
The main goals are to slow cancer growth and improve quality of life.
Participation involves close monitoring and regular hospital visits.
You have the right to withdraw from the study at any time.

Who may be eligible?

To be considered for this study, you must be an adult aged 18 years or older. There is no upper age limit, so older adults can also take part if they are suitable.

Both men and women are welcome to participate in this research. The study needs a diverse group of people to understand how the treatments work across different individuals.

The study is specifically for people who have been diagnosed with advanced pancreatic cancer. Your medical team will carefully check your health and your specific cancer details to see if this study is suitable for you.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Have you been diagnosed with advanced pancreatic cancer?
Are you able to attend regular hospital appointments?
Are you willing for your cancer cells to be tested in detail?
Are you open to potentially receiving either a tailored or standard treatment?

Answer every question to see your result.

What does participation involve?

If you decide to take part in this study, you would first have detailed tests to examine your cancer cells closely. Based on these results, you would be assigned to either a 'tailored' treatment group or a 'standard care' group. You would receive regular medication, which could be in various forms like pills, injections, or infusions, depending on the specific drug.

You would have frequent visits to the hospital or clinic for check-ups, blood tests, and scans to monitor your health and how the treatment is working. The exact number of visits and tests would depend on the treatment you receive and your individual progress, but it would involve more frequent appointments than routine care.

Throughout the study, you would be closely monitored for any side effects. Your quality of life would also be regularly assessed through questionnaires. The total duration of your participation would depend on how your treatment progresses, and there would be follow-up appointments even after you stop receiving the study treatment.

Potential risks and benefits

Taking part in this study could offer you access to new, tailored treatments that are not yet widely available. There's a chance these personalised approaches might control your cancer for longer or improve your quality of life. However, like all medical treatments, there are potential risks, including side effects from the medications, which your doctor will discuss in detail. There's also no guarantee that the tailored treatment will be more effective than standard care for your particular case. You are free to withdraw from the study at any time, for any reason, without it affecting your future medical care.

Locations (1)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

—
Unverified
Denmark

Common questions

What does 'advanced pancreatic cancer' mean?

It means the cancer has spread beyond where it started in the pancreas, or it cannot be removed with surgery.

What is 'molecularly tailored therapy'?

It means choosing a treatment based on the specific genetic makeup and features of your unique cancer cells, rather than a standard treatment for everyone.

Will I definitely get a tailored treatment if I join?

Not necessarily. Your cancer's features will be tested. Depending on those results and the study design, you might receive a tailored treatment or a standard cancer treatment.

What if the treatment isn't working for me?

Your medical team will closely monitor your progress. If the treatment isn't effective or if side effects are too severe, they will discuss other options with you, and you can stop participating at any time.

How long will I be in the study?

The length of time you participate can vary. It depends on how you respond to the treatment and your health, but your doctors will discuss the expected duration with you.