Understanding the Genetic and Biological Factors That Influence Cancer Treatment Response and Resistance in Patients With Advanced Solid Tumours Through Sample Analysis
This study explores genetic changes in advanced solid cancers to understand why treatments work differently for people. Researchers will analyse existing tissue samples and blood samples to find specific 'switches' that make cancer grow or respond to treatment. The goal is to see if these changes can predict which treatments will be most effective, helping doctors match patients to the right clinical trials and develop more personalised cancer care. This study does not involve new treatments but gathers important information that could improve future cancer care for others.
At a glance
What is this study about?
This study is trying to understand more about advanced solid cancers and how they respond to treatments. Imagine your cancer cells have tiny 'switches' inside them. Sometimes, these switches get stuck in the 'on' position, making the cancer grow, spread, or survive. This study aims to find these altered switches, also called mutations, in adults who have advanced solid cancers.
Researchers will look at samples already collected, like pieces of tissue from previous operations or biopsies, as well as new samples like blood. By studying these samples, they want to see if they can predict which treatments might work best for different people. This information could help doctors choose the most suitable clinical trials for patients and pave the way for more 'personalised' cancer treatments – meaning treatments tailored specifically to an individual's cancer.
It's important to know that this study isn't testing a new treatment itself. Instead, it's about gathering vital information. The findings could help us understand cancer better, discover new ways to fight it, improve how patients are chosen for future trials, and ultimately lead to more effective and individualised cancer care for everyone.
Key takeaways
- The study helps understand genetic changes in advanced solid cancers.
- Aims to predict which treatments work best for different people.
- Uses existing tissue samples and optional new samples like blood.
- No new treatments are given as part of this study.
- Information gained could lead to more personalised cancer care.
- You'll be told if any important findings relevant to your care are found.
Who may be eligible?
You might be able to take part in this study if you are an adult aged 18 or over and have been diagnosed with an advanced solid cancer. This means your cancer has been confirmed by medical tests.
You would also need to be either currently considering joining an early-phase clinical trial, or already taking part in one. Finally, you must be able to understand the study and agree to take part by signing a consent form.
Could this study suit you?
Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.
- Are you 18 years old or older?
- Do you have a confirmed diagnosis of advanced solid cancer?
- Are you considering or already participating in an early-phase cancer clinical trial?
- Are you able to understand and sign a consent form to join the study?
What does participation involve?
If you decide to take part, you'll first need to give your permission by signing a consent form. Researchers will then look at tissue samples that have already been collected from you, such as during a biopsy or surgery in the past. They will also collect and review your medical information about your cancer, the treatments you've had, and any clinical trials you've been in.
You might also be asked to provide some extra samples, like blood, urine, saliva, or even a cheek swab, if it's suitable for your situation. These additional samples would only be collected when medically appropriate. Researchers will then analyse all these samples to understand the tiny changes in your cancer cells. They will follow your progress by looking at your medical records over time. This study does not involve taking any new medication or specific treatments as part of the research itself.
Potential risks and benefits
Locations (2)
- Royal Marsden NHS Foundation Trust - Drug Development UnitVerified postcodeSutton, United Kingdom· Recruiting
- Royal Marsden NHS Foundation Trust - Prostate Cancer Targeted Therapy GroupVerified postcodeSutton, United Kingdom· Recruiting
Common questions
Will this study offer me a new treatment?
No, this study is observational, meaning it collects information and samples but does not provide any new treatments or medicines.
What kind of samples will be used?
Researchers will use samples already collected from you, like tissue from past biopsies. You might also be asked for optional samples like blood, urine, or saliva.
Will I get results from the study?
If any important findings that could be relevant to your cancer care are discovered, you and your doctor will be told.
How long does taking part last?
The study involves looking at your medical records over time to monitor your health outcomes and the safety of any sample collections.
Is my personal information kept private?
Yes, all your personal and medical information will be kept confidential and handled with care to protect your privacy.
How to find out more
Jessica Maudsley
Always speak to your GP or specialist before deciding to take part in a study.
Interested in taking part?
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