RecruitingNAINTERVENTIONAL

Hyaluronic Acid Filler Migration

This study investigates how common face fillers, called hyaluronic acid (HA) fillers, behave after they're injected. Many people use these fillers to add volume or improve facial contours. There are different types of HA fillers, and they have slightly different properties. The study aims to understand how these different types settle into the skin and whether they tend to move from the original injection site in the short and medium term. It's thought that thicker fillers might be less likely to move than thinner, more fluid ones. However, doctors' knowledge of face anatomy, safe injection methods, and choosing the right filler for the job are also important for preventing fillers from moving. By looking closely at how these fillers spread or stay put, this research hopes to provide clearer information.

At a glance

Status

Recruiting

Phase

Sponsor

Erevna Innovations Inc.

Enrolment target

Start

11 Dec 2025

Estimated completion

01 Dec 2027

Aesthetic

What is this study about?

You might have heard of or even considered getting hyaluronic acid (HA) fillers to help refresh your face, perhaps to restore some lost volume or improve your facial shape. These treatments have become quite popular. What many people don't know is that there are different types of HA fillers available, and they each have unique characteristics. These different types are designed to work in slightly different ways once they're under your skin. This study wants to understand how these various fillers spread out or settle in the face, and especially whether they tend to move from the area where they were originally injected.

The idea is that some fillers, particularly thicker ones, might stay in place better than those that are more fluid. However, it's also believed that a doctor's deep understanding of facial structure, using safe injection methods, and carefully choosing the right filler for your specific needs are all very important in preventing any unwanted movement of the filler. This research will specifically look at two main families of HA fillers to see how they behave after injection.

The main goal is to observe how these fillers are distributed in your face shortly after treatment and then again a bit later. The researchers want to gather evidence to see if fillers actually move from their intended spot, and if so, what might be contributing to that movement. This information could help doctors make even better choices about which fillers to use and how to inject them, leading to even safer and more effective treatments for people seeking facial rejuvenation.

Key takeaways

This study investigates how common face fillers behave after injection.
It aims to see if different types of fillers spread out or stay in place.
Understanding filler movement is important for safer and more effective treatments.
Participation involves receiving Restylane fillers and attending follow-up appointments.
You must be at least 18, generally healthy, and not had recent facial fillers.

Who may be eligible?

To join this study, you need to be at least 18 years old, male or female. You should also have some visible facial volume loss or areas where you'd like to improve the contour of your face. It's important that you haven't had any other facial fillers in the 18 months before starting this study.

You also need to be generally healthy, as decided by the study doctor, and be able to understand and agree to the study process. You must be able to attend all your scheduled follow-up appointments. If you are a woman who could become pregnant, you'll need to agree to use a reliable form of contraception during the study and for at least 30 days afterwards.

There are also some reasons you wouldn't be able to join. For example, you can't be pregnant or breastfeeding. You also can't participate if you have ever had a bad reaction or allergy to Restylane products, HA fillers, or certain local anaesthetics. People with certain liver conditions, heavy smokers (more than 12 cigarettes a day), or those with a history of severe allergic reactions might also not be able to join. If you've had other facial treatments like lasers in the past 6 months in the area being studied, you also wouldn't be eligible.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Do you have some facial volume loss or contour changes you'd like to address?
Have you avoided any other facial fillers for the past 18 months?
Are you able to attend all planned follow-up appointments?
If you could become pregnant, are you willing to use reliable birth control during the study?

Answer every question to see your result.

What does participation involve?

If you decide to take part in this study, you won't be able to have any other facial procedures for the entire duration of the study. You'll need to commit to attending all your scheduled follow-up appointments, so the researchers can observe how the fillers settle. The study doesn't mention specific details about the number of visits or the total length of time you'd be involved, but a research team member would explain this fully. You would receive injections of Restylane fillers as part of the study, and clinic staff would monitor the changes in your face over time.

Potential risks and benefits

Taking part in this study could help advance our understanding of how facial fillers work, potentially leading to better and safer treatments for everyone in the future. You might also benefit from receiving facial filler treatment, which aims to restore volume and improve your facial contours. As with any medical procedure, there are potential risks, such as allergic reactions to the fillers or an anaesthetic, or the filler moving from where it was intended. The study team would discuss all known possible side effects and risks with you in detail. Remember, you have the right to withdraw from the study at any time, for any reason, without it affecting your usual medical care.

Locations (1)

Erevna Innovations Inc.
Verified postcode
Westmount, Canada· Recruiting

Common questions

What are hyaluronic acid (HA) fillers?

HA fillers are gel-like substances injected into the face to restore lost volume, smooth lines, and enhance facial contours. They are a common aesthetic treatment.

Why are researchers studying filler movement?

They want to understand if fillers spread out or stay where they're injected, as this an important factor for safe and effective treatment results. Understanding this can help improve future treatments.

What does 'filler migration' mean?

'Filler migration' means the filler moving from the exact spot where it was originally injected to another area of the face.

Will I know which type of filler I receive?

The study aims to observe different types of fillers. The research team would explain what type you would receive and how that fits into the study design during your consent process.

Is getting a filler injection safe in a study?

All medical studies have to follow strict safety rules and are reviewed by an independent ethics committee. The medical team will discuss all potential risks and side effects with you before you agree to participate.

How to find out more

Laura Raco

lraco@vicpark.com 514-488-0163 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.