Evaluating Treatable Traits Across the Spectrum of Chronic Obstructive Airways Disease
This study is exploring different long-term breathing conditions, such as asthma, COPD, and cystic fibrosis. Many people in the UK live with these conditions, which can make it hard to breathe, limit activity, and affect overall well-being. Doctors are trying to find more personalised ways to treat these conditions by looking at individual 'treatable traits' — specific features that can be targeted with different therapies. Most research so far has focused on COPD and asthma, so this study aims to expand our understanding to other breathing problems. By comparing how these conditions affect the lungs and other parts of the body, and how specific traits link to physical activity and quality of life, researchers hope to improve care for everyone with long-term airway diseases.
At a glance
What is this study about?
Imagine you have a long-term breathing problem – things like asthma, COPD, or cystic fibrosis. These conditions can make everyday activities feel much harder, leaving you breathless and affecting your overall quality of life. Currently, doctors often treat these illnesses in similar ways, but what if we could tailor treatments more precisely to each person?
This study is trying to do just that. It's looking at different types of long-term breathing conditions to understand them better. Think of it like this: even though many people have a "breathing problem," the exact causes and effects can be quite different from person to person. Researchers want to identify specific features or 'treatable traits' within each person's condition. By understanding these individual traits, doctors hope to offer more personalised treatments that specifically target what's causing problems for you.
The main goals are to compare how different breathing conditions affect the lungs and other parts of the body, and to see how these 'treatable traits' are connected to how active someone is and how well they feel. Up until now, most of this kind of research has focused mainly on asthma and COPD, so this study is important because it’s looking at a wider range of conditions. Ultimately, the aim is to find better ways to help people manage their breathing problems and live fuller, more active lives.
Key takeaways
- The study explores a range of long-term breathing conditions.
- It aims to find more personalised treatments.
- Your participation helps improve care for future patients.
- It involves assessments like breathing tests, not new medications.
- You can withdraw from the study at any time.
- The research focuses on ages 18-65 who have a diagnosed airway disease.
Who may be eligible?
To join this study, you generally need to be between 18 and 65 years old. You should have already received a diagnosis of a long-term breathing condition, based on established medical guidelines. The study is also looking for people who don't currently smoke or have quit smoking. It's important that you can understand and speak English well enough to follow instructions and give your consent to take part.
There are also some things that would mean you can't join. For example, if you've had a severe flare-up of your breathing condition needing hospitalisation or strong steroid tablets in the last two months, you wouldn't be eligible. Also, if you have certain other health conditions like serious heart problems, kidney issues, or are receiving oxygen therapy, or if you can't walk easily, this study might not be suitable for you. If you are pregnant or think you might be, you also wouldn't be able to participate.
- Do you have a pre-existing diagnosis of a breathing condition?
- Are you between 18 and 65 years old?
- Are you a non-smoker or ex-smoker?
- Have you not had a severe flare-up of your breathing condition in the last two months?
- Are you able to speak and understand English fluently?
This is a guide only — the research team will confirm whether you can take part.
What does participation involve?
If you decide to take part, you'll visit a clinic for a thorough check-up. This will involve several tests to understand how your lungs are working, including breathing tests (pulmonary function testing). You might also have tests to see how well you can exercise. The study won't involve taking any new medications. You'll simply undergo assessments to help the researchers gather information about your condition. The overall time commitment would involve attending these appointments, and the team will explain the total duration of your participation, including any follow-up required.
Potential risks and benefits
Locations (1)
- University of LeedsLeeds, United Kingdom· Recruiting
Common questions
What kind of breathing conditions are included?
The study includes various long-term breathing problems such as COPD, asthma, bronchiectasis, cystic fibrosis, and primary ciliary dyskinesia.
Will I have to take new medication?
No, this study does not involve taking or trying any new medications. It focuses on assessments and tests.
What is 'pulmonary function testing'?
This is a common set of breathing tests that measure how well your lungs are working, to see how much air you can breathe in and out, and how quickly.
How long will I need to participate?
The study team will explain the exact number of visits and the total time commitment when you discuss joining the study.
What is the study hoping to achieve?
Researchers hope to understand different breathing conditions better, identify individual 'treatable traits', and ultimately improve how these conditions are diagnosed and managed for patients.
How to find out more
Oliver Price, PhD
Always speak to your GP or specialist before deciding to take part in a study.
Interested in taking part?
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