RecruitingNAINTERVENTIONAL

Rehab Study for alloBMT Patients

This study, called 'Rehab Study for alloBMT Patients', is looking into a new programme, CaRE-4-alloBMT, designed to help people recover after an allogeneic bone marrow transplant. An allogeneic transplant means you receive healthy blood stem cells from a donor. The aim is to see how well this programme works in a real-world setting compared to the standard care patients usually receive. Researchers want to understand if this programme helps patients with their physical activity, nutrition, and overall well-being. Participants will be split into two groups: one receiving the new CaRE-4-alloBMT programme and the other receiving usual care. Their progress will be checked at several points over about six months after leaving hospital.

At a glance

Status

Recruiting

Phase

Sponsor

Jennifer Jones

Enrolment target

208

Start

01 Oct 2025

Estimated completion

30 Aug 2028

Allogenic Bone Marrow Transplantation

What is this study about?

This study is called the 'Rehab Study for alloBMT Patients' and it's looking into a special programme called CaRE-4-alloBMT. This programme is designed to help people who have had a type of transplant called an allogeneic bone marrow transplant (alloBMT). This transplant is used to treat certain blood cancers, and it involves replacing unhealthy bone marrow with healthy cells from a donor. Recovering from an alloBMT can be a long process, and this study wants to find the best ways to support patients during this time.

The main aim of this study is to see how well the CaRE-4-alloBMT programme works compared to the standard care patients usually receive. The programme focuses on helping people be more active, eat well, manage common side effects, and generally improve their recovery and well-being. Researchers are carrying out a 'pragmatic trial', which means they are checking the programme in a real-life hospital setting to see if it can genuinely help a wide range of patients. They also want to understand if this programme can be successfully used more widely.

Taking part in the study means you would be randomly put into one of two groups. One group will receive the new CaRE-4-alloBMT programme along with their usual care. The other group will receive their standard usual care, which includes resources on exercise and healthy eating. By comparing these two groups, doctors can learn if the new programme makes a real difference to patient recovery after a bone marrow transplant. This could help improve care for many people in the future.

Key takeaways

This study aims to improve recovery for people after a bone marrow transplant.
It tests a new programme called CaRE-4-alloBMT against standard care.
The programme supports exercise, nutrition, and managing side effects.
Participants will be randomly assigned to one of two care groups.
The study lasts from before transplant until 6 months after hospital discharge.
Your progress will be checked at several points over this time.

Who may be eligible?

You might be able to take part in this study if you are scheduled to have an allogeneic bone marrow transplant at Princess Margaret Hospital. You need to be at least 18 years old and having treatment for a blood cancer. It's also important that you can access study materials online and understand English, both spoken and written.

There are some reasons why you might not be able to join. For example, if your hospital admission for the transplant is less than two weeks away from when the study would start, as there wouldn't be enough time for the warm-up phase of the programme. Also, if you are already taking part in another clinical trial or similar support study, or if you have any health conditions or muscle/bone problems that would stop you from safely doing the exercise programmes.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you having an allogeneic bone marrow transplant at Princess Margaret Hospital?
Are you 18 years old or older?
Are you having treatment for a blood cancer?
Can you use online materials for the study?
Can you understand and speak English?
Is your hospital admission for transplant more than two weeks away?

Answer every question to see your result.

What does participation involve?

If you decide to take part in this study, the first step will be to fill out some questionnaires and have an initial meeting with a trained exercise specialist. After this, you will be randomly assigned to one of two groups: either the CaRE-4-alloBMT programme group or the 'usual care' group.

If you are in the CaRE-4-alloBMT group, you will receive the special programme starting about 4 to 8 weeks before your transplant and continuing for 6 months after you leave the hospital, lasting roughly 8 to 9 months in total. This programme will involve personalised support to help you with physical activity, nutrition, and managing side effects. If you are in the usual care group, you will receive the standard support given to all patients, including guidance on exercise and healthy eating.

Throughout the study, you will be asked to complete questionnaires and have physical health checks at several points: at the very start (before your transplant), when you are admitted to hospital, when you are discharged from hospital, and then again 3 months and 6 months after you go home. The aim is to track your progress and recovery over this time.

Potential risks and benefits

Participating in this study might offer some potential benefits, such as receiving extra support and guidance on exercise, nutrition, and managing side effects through the CaRE-4-alloBMT programme. Even if you are in the usual care group, your participation helps researchers learn more about how to best support patients like you. There are no known major risks specifically from taking part beyond those generally associated with exercise programmes and your bone marrow transplant recovery within a clinical setting. You have the right to withdraw from the study at any time, for any reason, without it affecting your medical care.

Locations (1)

Princess Margaret Cancer Centre
Verified postcode
Toronto, Canada· Recruiting

Common questions

What is an 'allogeneic bone marrow transplant'?

It's a medical procedure where you receive healthy blood stem cells from a donor to replace unhealthy ones, usually to treat certain blood cancers.

What is the CaRE-4-alloBMT programme?

It's a special programme designed to help people recover after an allogeneic bone marrow transplant, focusing on physical activity, healthy eating, and managing side effects.

How long does the study last?

The CaRE-4-alloBMT programme itself, if you're in that group, runs from approximately 4-8 weeks before your transplant until 6 months after you leave hospital. Your participation with assessments will also cover this period.

Will I definitely get the new CaRE-4-alloBMT program?

No, you will be randomly put into one of two groups: either the CaRE-4-alloBMT program group or the usual care group. It's like flipping a coin.

What happens if I decide to leave the study?

You can leave the study at any time and for any reason. Your decision will not affect the medical care you receive.

How to find out more

Jennifer M Jones, PhD

jennifer.jones@uhn.ca 14165818603 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.