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Ongoing, recruitingTherapeutic confirmatory (Phase III)Interventional

Serotonin role on brain circuits involved in food avoidance in anorexia nervosa : Study of Gaze control and multimodal Brain imaging.

This study is investigating how serotonin, an important chemical in the brain, might be linked to why people with anorexia nervosa avoid food. Researchers are using advanced brain imaging techniques and tracking eye movements to understand the brain circuits involved. It's a Phase III trial, meaning it's a later stage study designed to confirm findings from earlier research. The main goal is to measure how a specific serotonin-related marker behaves in the brain. They will also look at brain blood flow, brain connections, activity levels, and how participants choose foods. The aim is to gather more knowledge that could eventually help develop better treatments for anorexia nervosa.

At a glance

Status
Ongoing, recruiting
Phase
Therapeutic confirmatory (Phase III)
Sponsor
Centre Hospitalier Universitaire De Saint Etienne
Enrolment target
75
Start
30 Jan 2025

What is this study about?

This study is trying to understand more about anorexia nervosa, a serious eating disorder where people intensely fear gaining weight and often have a distorted body image. Researchers believe that a brain chemical called serotonin might play a big role in why people with anorexia nervosa avoid certain foods. This study will use very advanced scanning techniques to look at the brain and see how serotonin is working.

They're particularly interested in how serotonin affects the brain circuits (pathways) that control things like avoiding food. By using a combination of special brain scans, like PET and MRI, alongside tracking eye movements when people look at food, scientists hope to get a clearer picture of what's happening in the brain. They will also ask participants about their feelings towards food to understand their choices and preferences.

This research is important because the more we understand about the brain processes involved in anorexia nervosa, the better we can develop new and more effective treatments in the future. It’s part of a bigger effort to help people with this condition. This study is in a later stage (Phase III), which means previous research has already suggested that looking at serotonin could be a promising area.

Key takeaways

  • This study focuses on understanding the brain in anorexia nervosa.
  • It investigates how brain chemicals like serotonin relate to food choices.
  • Advanced brain scans and eye-tracking will be used for research.
  • Participation is for women aged 18 and older with anorexia nervosa.
  • The goal is to improve future treatments for anorexia nervosa.

Who may be eligible?

To be considered for this study, you must be a woman aged 18 or older with anorexia nervosa. There is no upper age limit, meaning women of any adult age can potentially take part.

It's important to note that the study is specifically looking for female participants. If you have been diagnosed with anorexia nervosa and meet the age requirement, this study might be suitable for you.

Quick self-check
  • Are you female?
  • Are you 18 years old or older?
  • Have you been diagnosed with anorexia nervosa?
  • Are you able to travel to the study site for appointments?

This is a guide only — the research team will confirm whether you can take part.

What does participation involve?

If you take part in this study, you will have several appointments involving special brain scans like PET and MRI. These scans help researchers see how your brain is working and how a certain chemical (serotonin) behaves. You will also have your eye movements tracked while looking at different food items to see how you respond to them. Additionally, you'll complete questionnaires about your eating habits, mood, and feelings of anxiety. Researchers will also check your hormone and nutrition levels. The study involves taking a specific substance (3-AMINO-4-[2-[[METHYL((111C)METHYL)AMINO]METHYL]PHENYL]SULFANYLBENZONITRILE) as part of the PET scan process. The total duration of your participation will be explained by the study team.

Potential risks and benefits

Participating in this study might offer the benefit of contributing to new scientific understanding that could help others with anorexia nervosa in the future. You will also receive detailed health assessments. Potential risks might include discomfort or side effects from the study substance used in the PET scan, or anxiety associated with the assessments and discussions about eating behaviours. All procedures, including scans, carry some minor risks which will be fully explained. You have the right to withdraw from the study at any time without giving a reason, and your medical care will not be affected.

Locations (1)

  • France

Common questions

What is anorexia nervosa?

Anorexia nervosa is a serious eating disorder where people restrict food, have an intense fear of gaining weight, and a distorted body image.

What are brain scans like?

Brain scans like MRI and PET are pain-free procedures where you will lie still in a scanner. They help doctors see inside your brain.

Will taking part help me directly?

While this study contributes to understanding anorexia nervosa, it's not designed to treat your condition directly, but it may offer detailed assessments.

Is the study open to men?

No, this particular study is only looking for women participants aged 18 and over.

What happens if I change my mind about participating?

You are free to stop participating in the study at any time, for any reason, without affecting your medical care.

How to find out more

Always speak to your GP or specialist before deciding to take part in a study.

Discussion

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