RecruitingOBSERVATIONAL

Molecular Characterisation of Appendiceal Cancer

This study is investigating appendix cancer, a rare type of cancer that often spreads to the lining of the abdomen. Researchers are looking at tissue samples collected during past surgeries from patients aged 18 and over who had this cancer. By studying the DNA changes within these cancer cells, the team hopes to learn more about why the cancer spreads, how it develops, and why some treatments work better than others. The goal is to find new and more effective ways to treat appendix cancer, leading to more personalised care, better long-term survival for future patients, and an improved quality of life.

At a glance

Status

Recruiting

Sponsor

The Christie NHS Foundation Trust

Enrolment target

100

Start

04 Feb 2024

Estimated completion

03 Jul 2025

Appendiceal Cancer

What is this study about?

Appendix cancer is a very rare type of cancer that often spreads to the lining of the belly. When it spreads, it can cause serious health problems. The main treatment for this type of cancer is a very big and complicated operation. Because it's so rare, we don't know enough about what makes it tick, how to predict who will do well, and how to create new, better treatments. This research aims to fill some of those gaps.

This study will look at tissue samples from patients who have already had surgery for their appendix cancer. The researchers will examine the genetic material (DNA) within these cancer cells. They want to see if certain changes in the DNA can explain why the cancer started, why it spread, and how it reacted to any treatments the patient received. They'll compare the DNA of the original tumour in the appendix to the DNA of any cancer that spread to the belly lining to see what changes occurred.

Ultimately, the information gathered from this study could be very important. It could help doctors understand who is most likely to benefit from certain treatments, develop more personalised care plans, and lead to the discovery of completely new ways to fight appendix cancer. This could mean a better quality of life and longer lives for people diagnosed with this challenging disease in the future.

Key takeaways

This study focuses on understanding appendix cancer using past patient samples.
It aims to discover why the cancer spreads and how it develops.
Researchers will look at the DNA changes in cancer cells.
The goal is to find better and more personalised treatments for future patients.
No active participation is required; it uses existing medical data and stored tissue.
The study has no direct health risks for participants.

Who may be eligible?

This study is looking at information and samples from people who have already been diagnosed with appendix cancer.

You can be included in this study if you were 18 years old or older when you were diagnosed. You must also have had appendix cancer that spread to the lining of your abdomen, and you must have had a specific type of surgery to remove as much of the cancer as possible. Finally, there needs to be a sample of your cancer tissue available from your previous surgery that researchers can study.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Were you diagnosed with appendix cancer?
Did your cancer spread to the lining of your belly?
Did you have surgery to remove this cancer?
Were you at least 18 years old when you were diagnosed?

Answer every question to see your result.

What does participation involve?

If you meet the criteria, you won't need to do anything extra. This study is looking back at existing medical records and tissue samples that were collected as part of your routine care. You won't have any appointments, special assessments, or take any medication for this study. There is no follow-up required from you. Your participation relies solely on the use of archived tissue and medical information, meaning you won't be actively involved or need to attend any visits related to this research.

Potential risks and benefits

Because this study only uses samples and information from the past, there are no direct medical risks to you. You won't receive any direct medical benefits from taking part in this study, as the research is about understanding the disease for future patients. However, the information gained may help improve treatments for others with appendix cancer in the future. You have the right to withdraw your consent for your data and samples to be used at any time, without affecting your medical care.

Locations (1)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

The Christie NHS Foundation Trust
Verified postcode
Manchester, United Kingdom· Recruiting

Common questions

What kind of cancer is appendiceal cancer?

It's a rare cancer that starts in the appendix, a small finger-shaped organ attached to your large intestine.

What does 'peritoneal metastases' mean?

This means the cancer has spread from the appendix to the peritoneum, which is the lining of your abdominal cavity (belly area).

What are 'archival tumour tissue samples'?

These are pieces of your cancer that were saved and stored after your surgery. They can be looked at later for research.

Will I get my test results from this study?

No, because this study uses stored samples and looks at information on a group level, individual results will not be shared with patients.

How will this study help patients in the future?

By understanding the genetic changes in appendix cancer, researchers hope to find better ways to treat it and improve outcomes for future patients.

How to find out more

Richa Garvia

removed_due_to_spam@email.com 01614463000 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.