Effects of single-pill combination of telmisartan/amlodipine and telmisartan/amlodipine/hydrochlorothiazide on 24-hour blood pressure (BP) reduction, 24-h BP variability and office BP control in patients with arterial hypertension – SATELLITE
This study, called SATELLITE, is investigating several new combination medicines for people with high blood pressure. High blood pressure, also known as arterial hypertension, is when the force of blood against your artery walls is too high. The main goal is to understand how much these single-pill combinations can lower your blood pressure over a full 24-hour period after 16 weeks of treatment. Researchers will also check how steady your blood pressure stays and how well it's controlled when measured at the doctor's office. This research is important for finding better ways to manage high blood pressure and protect your heart and blood vessels.
At a glance
What is this study about?
This research study, known as SATELLITE, is focusing on new ways to treat high blood pressure, which doctors call arterial hypertension. High blood pressure is a very common condition where the force of your blood pushing against the walls of your arteries is consistently too high. If left untreated, it can lead to serious health problems like heart disease and stroke.
The study is looking at single pills that combine up to three different medicines: telmisartan, amlodipine, and hydrochlorothiazide. These medicines work in different ways to help relax blood vessels and remove extra fluid from your body, which helps to lower blood pressure. The main aim is to see how much these combination pills can reduce your blood pressure over a full 24-hour day, not just when you're at the doctor's office. They're also checking how stable your blood pressure stays throughout the day and how well it's controlled when measured during a doctor's visit.
Researchers will be measuring changes in blood pressure over 16 weeks of treatment. They will look at both the top number (systolic blood pressure) and the bottom number (diastolic blood pressure). This study is important because finding effective and convenient treatments can help more people manage their high blood pressure better, potentially reducing their risk of serious health complications in the long run. It also helps doctors understand which treatments work best for different individuals.
Key takeaways
- New combination pills for high blood pressure are being tested.
- The study measures how blood pressure changes over 24 hours.
- Participants will be treated for 16 weeks.
- It aims to find better ways to manage high blood pressure.
- Open to adults aged 18 and over with high blood pressure.
Who may be eligible?
This study is open to both men and women who are at least 18 years old. There's no upper age limit, meaning older adults can also take part if they meet other criteria.
To be eligible, you must have high blood pressure, also known as arterial hypertension. The research team will need to confirm your diagnosis and ensure your high blood pressure meets specific criteria for the study.
There might be other health requirements or conditions that would prevent someone from joining, such as certain other medical conditions or medications you are currently taking. The study team will discuss all of these details with you to make sure it's safe and appropriate for you to participate.
Could this study suit you?
Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.
- Are you 18 years old or older?
- Do you have a diagnosis of high blood pressure?
- Are you able to attend regular clinic visits for 16 weeks?
- Are you willing to take a study medication daily?
What does participation involve?
If you decide to take part in this study, you would receive one of the combination pills being tested for your high blood pressure. You would take this medication as prescribed for a period of 16 weeks. Throughout this time, you would have several visits to the clinic, likely at weeks 4, 8, 12, and 16, in addition to an initial visit.
During these visits, the study team would regularly check your blood pressure, both in the clinic and potentially using a special device that measures your blood pressure continuously over 24 hours. They might also perform other tests to monitor how the medication is affecting your body. All procedures, including medication and assessments, are part of the detailed study plan. The full duration of your active participation would be 16 weeks of treatment, with follow-up appointments during that period.
Potential risks and benefits
Locations (3)
- —UnverifiedSlovenia
- —UnverifiedHungary
- —UnverifiedPoland
Common questions
What is high blood pressure?
High blood pressure, or arterial hypertension, means your blood is pushing too hard against your artery walls. It can be serious if not treated.
What kind of medicines are being tested?
We are testing pills that combine different blood pressure medications (telmisartan, amlodipine, and hydrochlorothiazide) into one tablet.
How long does the study last?
If you join, you would take the study medicine for 16 weeks, with regular check-ups during that time.
What will researchers measure?
They will mainly measure how much your blood pressure changes over 24 hours and in the doctor's office, and how steady it stays.
Can I stop participating if I want to?
Yes, you are free to leave the study at any time, for any reason, without affecting your medical care.
How to find out more
Always speak to your GP or specialist before deciding to take part in a study.
Discussion
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