A Study to Evaluate the Efficacy and Safety of Icotrokinra (JNJ-77242113) in Biologic-experienced and Biologic-naive Participants With Active Psoriatic Arthritis

To be able to join this study, you would need to be an adult (18 years or older) and have active psoriatic arthritis. This means you would have been diagnosed with psoriatic arthritis for at least 3 months and still experience noticeable joint pain and swelling, specifically at least 3 swollen and 3 tender joints. You would also need to have active psoriasis, such as a patch of skin psoriasis at least 2cm wide or changes to your nails caused by psoriasis.

It's important that your psoriatic arthritis hasn't responded well to at least one previous treatment, whether that was an older type of arthritis medicine (like a non-biologic DMARD), apremilast, or one biologic medicine. There are certain health conditions that would prevent you from taking part, such as having severe kidney, liver, heart, or lung problems, or a history of cancer within the last five years. Also, if you have other inflammatory conditions like rheumatoid arthritis, it's likely you wouldn't be able to join. If you are a woman who could become pregnant, you would need to have negative pregnancy tests before starting the study medicine.

If you decide to take part in this study, you would receive either the new medicine, icotrokinra, or a placebo (a dummy medicine). You wouldn't know which one you are receiving. You would need to attend regular clinic visits where the study team would check your health, assess your psoriatic arthritis symptoms, and take blood samples. They would also monitor you closely for any side effects. The exact number of visits and the total length of your participation would be explained to you in detail by the study team, but typically these types of studies involve several visits over a period of many months.