A Study to Evaluate the Efficacy and Safety of JNJ-77242113 (Icotrokinra) in Biologic-naïve Participants With Active Psoriatic Arthritis

This study is looking for adults aged 18 or older who have been diagnosed with psoriatic arthritis for at least three months. To be considered, your psoriatic arthritis needs to be 'active,' meaning you have a certain number of swollen and tender joints, and a blood test shows signs of inflammation. You should also have at least one type of psoriatic arthritis that affects specific joints or your spine, and at least one patch of active psoriasis on your skin or nail changes related to psoriasis.

It's important that you have not previously received any 'biologic' medicines for your psoriatic arthritis or psoriasis. People with other serious illnesses affecting their organs like kidneys, liver, or heart, or other inflammatory diseases like rheumatoid arthritis, cannot join. Also, if you have severe allergies to the study medicine or its ingredients, or if other conditions like fibromyalgia might make it hard to measure how well the treatment is working, you would not be able to participate. Women who could become pregnant will need to take pregnancy tests and use effective contraception during the study.

If you decide to take part in this study, you would be given either the new medicine (icotrokinra), a dummy medicine (placebo), or an existing treatment. This would involve regular visits to the clinic for check-ups, where doctors and nurses would monitor your psoriatic arthritis symptoms by examining your joints and asking about your well-being. You would also have blood tests and other assessments to check your general health and see how the treatment is affecting you.

More detailed information about visit schedules, specific tests, and the total length of the study would be given to you by the study team. They will explain everything you need to know before you make a decision. Remember, you can ask as many questions as you like throughout the process.