Active not recruitingOBSERVATIONAL

First-Line Diagnostic Investigations for Suspected Adult Asthma

Asthma can be tricky to diagnose because its symptoms, like breathlessness or a cough, can be caused by other things. Sometimes, people with asthma even have normal breathing tests. This study wants to find out which common tests, or combinations of tests, are most accurate for diagnosing asthma in adults. Participants referred to George Eliot Hospital for suspected asthma will undergo several routine breathing tests over two visits. The study will then compare these test results with the final diagnosis to see how well each test works. The goal is to make asthma diagnosis faster and more accurate, helping people get the right treatment sooner.

At a glance

Status

Active not recruiting

Sponsor

George Eliot Hospital

Enrolment target

2,176

Start

02 Aug 2026

Estimated completion

30 Jul 2028

Asthma (Diagnosis)

What is this study about?

Asthma is a common long-term condition that makes breathing difficult. However, it can be quite hard to diagnose correctly. This is because symptoms like feeling breathless, wheezing, or coughing can change over time and might be caused by other health issues. Also, some people with asthma can have normal results on their breathing tests, which makes getting a clear diagnosis even more challenging and can delay getting the right treatment.

This study is looking into the most effective ways to diagnose asthma in adults. We want to find out which of the commonly used breathing tests, either on their own or when combined, are the most accurate for finding out if someone has asthma. People who are referred to George Eliot Hospital because their doctor suspects they might have asthma will be invited to take part. By comparing how different tests perform, we hope to improve how doctors diagnose asthma every day.

Ultimately, the aim is to make diagnosing asthma faster and more precise. This could mean fewer unnecessary tests, and people getting the correct diagnosis and starting treatment sooner. This improved understanding could lead to better care for everyone who might have asthma.

Key takeaways

This study aims to find the most accurate ways to diagnose asthma in adults.
It compares common breathing tests to see which work best.
Participants will have two visits for routine breathing tests at George Eliot Hospital.
The goal is to improve how asthma is diagnosed, making it faster and more precise.
Better diagnosis can lead to better care and getting the right treatment sooner.
You can only join if referred for suspected asthma and are 16 or older.

Who may be eligible?

To be able to take part in this study, you need to be an adult, aged 16 years or older. You must also have been referred to George Eliot Hospital specifically because your doctor suspects you might have asthma and needs more tests to find out.

There are some reasons why you wouldn't be able to join. For example, if you've already been diagnosed with asthma or another long-term lung condition, or if you've had a chest infection in the last six weeks. People who currently smoke or used to smoke a lot (more than a 'pack-year' history) also can't take part. You also need to be able to do the breathing tests properly and be well enough for them.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 16 years old or older?
Have you been referred to George Eliot Hospital because your doctor thinks you might have asthma?
Have you *not* already been diagnosed with asthma or another long-term lung condition?
Have you *not* had a chest infection in the last six weeks?
Do you *not* currently smoke or have a significant past smoking history?
Are you able to do breathing tests when asked?

Answer every question to see your result.

What does participation involve?

If you decide to take part, you'll have two visits for your study appointments. During your first visit, you'll have several routine breathing tests. These include: * **Spirometry:** This is a common test where you blow into a machine to measure how much air your lungs can hold and how fast you can blow it out. You’ll do this before and after using a reliever inhaler. * **Fractional Exhaled Nitric Oxide (FeNO) test:** For this, you’ll breathe out slowly and steadily into a small device. It measures a gas in your breath that can show if there’s inflammation in your airways. * **Oscillometry:** This test also involves breathing normally through a mouthpiece to check how easily air moves through your lungs.

After these tests, you'll come back for a second visit. At this visit, you'll have a **bronchial provocation challenge test**. This test helps doctors see if your airways are extra sensitive, which is a key sign of asthma. The study will compare all these test results with your final diagnosis to see which tests are most helpful. You can withdraw from the study at any time.

Potential risks and benefits

Taking part in this study may help us understand better ways to diagnose asthma, which could lead to faster and more accurate diagnoses for others in the future. The tests you'll have are routine diagnostic tests, so any risks are generally small, similar to those you might experience during a standard clinic visit for suspected asthma. You have the right to withdraw from the study at any time, for any reason, without it affecting your care.

Locations (1)

Physiological Sciences
Verified postcode
Nuneaton, United Kingdom

Common questions

What is asthma?

Asthma is a common lung condition that causes occasional breathing difficulties. It can affect people of all ages.

What is 'plain English'?

Plain English means using simple, clear words and short sentences so that information is easy to understand for everyone, without needing special medical knowledge.

Will I get my test results?

Your doctors will use the results of these tests to help with your diagnosis and care, as they are standard tests. The study will collect information for research, but individual results will be used for your clinical care.

Will I be given treatment during the study?

This study is about diagnosis, not treatment. Any treatment decisions will be made by your regular doctor based on your diagnosis.

How long will the study visits take?

The study involves two visits. The exact duration of each visit will be explained to you when you are invited to take part.