The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)

To join this study, you need to be an adult of any age from 45 years upwards, and have a Body Mass Index (BMI) of 27 or higher. You must also have existing heart disease (like problems with your heart arteries, a history of stroke, or poor circulation in your legs) or certain levels of chronic kidney disease. If you have type 2 diabetes, your blood sugar levels (HbA1c) need to be 10% or less.

There are also reasons why you might not be able to join. For instance, if you have type 1 diabetes or have recently had a heart attack, stroke, or certain heart or circulation procedures in the last three months. You also can't take part if you have severe heart failure, very advanced kidney disease, are on dialysis, or have had a kidney transplant. Certain other conditions, like a history of pancreatitis, some types of thyroid cancer, or previous weight-loss surgery, would also prevent you from joining.

If you join this study, you'll be part of it for about five years. During this time, you will have up to 27 visits with the study doctor at the clinic. These visits are important for the team to monitor your health, give you the study medicine (either retatrutide or a placebo), and perform any necessary tests. They will also check how you are feeling and if you are experiencing any side effects. The medicine will likely be given as a once-weekly injection. You will be closely supported by the study team throughout your involvement.