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High Resolution Imaging for Analysis of MVNT

This study aims to get better images of a harmless brain condition called MVNT (multinodular and vacuolating neuronal tumour). Doctors have only recently discovered MVNT, and we don't know how common it is. It often appears in a specific part of the brain and looks a certain way on standard MRI scans. However, sometimes these scans aren't clear enough, and people might have unnecessary surgery to remove something that isn't harmful. This research will use very detailed MRI scans to help doctors get a clearer picture of MVNT. The goal is to improve how doctors diagnose this benign condition, so patients can avoid unnecessary invasive procedures.

At a glance

Status
Recruiting
Sponsor
Fondation Ophtalmologique Adolphe de Rothschild
Enrolment target
33
Start
05 Mar 2020
Estimated completion
19 May 2027

What is this study about?

This research is looking at a condition in the brain called MVNT, which stands for multinodular and vacuolating neuronal tumour. Don't let the long name worry you—it's actually a harmless (benign) condition. It's a fairly new discovery, so doctors are still learning a lot about it, including how often it occurs.

MVNT often shows up in a specific area of the brain, usually on standard MRI scans. However, sometimes these standard scans aren't clear enough. This can make it hard for doctors to be absolutely sure if it's MVNT or if it could be something more serious. When there's uncertainty, patients might end up having surgery to remove the growth, just to be safe. But if it turns out to be MVNT, that surgery wasn't needed.

This study wants to find a better way to look at MVNT. It will use very advanced MRI scanning techniques that can take much more detailed pictures of the brain. By getting these super-clear images, doctors hope to become much better at identifying MVNT accurately. This means they can avoid unnecessary surgery for patients and provide clearer answers about their condition.

Key takeaways

  • This study uses detailed MRI scans to better understand a harmless brain condition called MVNT.
  • The goal is to improve diagnosis and prevent unnecessary surgery for MVNT.
  • MVNT is a benign (non-cancerous) condition, only recently discovered.
  • Participants must be over 18 and suspected of having MVNT based on initial scans.
  • The study primarily involves advanced MRI scanning, no new medication.
  • You can withdraw from the study at any time.

Who may be eligible?

To be part of this study, you need to be an adult, aged 18 or older. Doctors will consider you if your first brain scan (MRI) caused them to suspect you might have MVNT. To be 'suspected' of having MVNT, your scan needs to show certain features: two main signs and at least one other minor sign that doctors look for.

You cannot join the study if you have any reason why you shouldn't have an MRI scan, for example, if you have certain metal implants in your body. Also, pregnant or breastfeeding women cannot take part, nor can anyone who is legally unable to agree to participate.

Importantly, before you can join, you'll be given full information about the study so you understand what's involved, and you'll need to give your clear permission to take part.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

  1. Are you 18 years old or older?
  2. Did your first brain scan suggest you might have MVNT?
  3. Do you have any metal in your body that prevents you from having an MRI?
  4. Are you pregnant or breastfeeding?
  5. Are you able to understand information about studies and give your full permission to take part?
Answer every question to see your result.

What does participation involve?

The specific details about what taking part involves are not fully described in the provided information. However, based on the study's focus, it is highly likely that participation would involve undergoing one or more special MRI scans of your brain, which might be more detailed or involve different techniques than a standard MRI. You would not be given any new medication as part of this study. The main involvement would be the imaging, and doctors will be using the information from these advanced scans to characterise your existing condition.

Potential risks and benefits

The main benefit of taking part in this study is helping doctors better understand MVNT. This could lead to a more accurate diagnosis for future patients, potentially preventing unnecessary surgery for a harmless condition. The risks associated with this study are generally low, as it primarily involves MRI scans, which are safe for most people. However, anyone with certain metal implants or other conditions might not be able to have an MRI. You are free to withdraw from the study at any time without giving a reason, and this will not affect your future medical care.

Locations (7)

  • Groupe Hospitalier Pellegrin
    Verified postcode
    Bordeaux, France· Active not recruiting
  • CHU Rennes
    Verified postcode
    Rennes, France· Recruiting
  • CHU de Rouen
    Verified postcode
    Rouen, France· Active not recruiting
  • Hôpital Pierre Paul Riquet, CHU Purpan
    Verified postcode
    Toulouse, France· Active not recruiting
  • Fondation A De Rothschild
    Verified postcode
    Paris, France· Recruiting
  • Centre Hospitalier Lyon Sud
    Verified postcode
    Pierre-Bénite, France· Active not recruiting
  • Hôpital Laennec
    Verified postcode
    Saint-Herblain, France· Recruiting

Common questions

What is MVNT?

MVNT is a recently discovered, harmless (benign) growth in the brain. It's not cancerous and doesn't usually cause problems.

Why is this study important?

Currently, standard brain scans can sometimes make it hard to tell MVNT apart from other, more serious conditions. This study hopes to improve diagnosis so people don't have unnecessary surgery.

What is an MRI?

An MRI (Magnetic Resonance Imaging) is a type of scan that uses strong magnets and radio waves to create detailed pictures of the inside of your body, including your brain.

Will I be given new medication if I join?

No, this study does not involve giving any new medication. It focuses on using advanced scanning techniques to get better images of your brain.

Can I change my mind about participating?

Yes, you can decide to leave the study at any time, for any reason, without it affecting your medical care.

How to find out more

Amelie YAVCHITZ, PhD

Always speak to your GP or specialist before deciding to take part in a study.

Interested in taking part?

Register your interest

Share your details and the research team for "High Resolution Imaging for Analysis of MVNT…" will contact you if you may be eligible. Always speak to your GP before agreeing to take part.

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