A Study to Evaluate the Efficacy, Safety, and PK of AZD0292 Administered IV in Participants 12 Years of Age and Older With Bronchiectasis and Chronic Pseudomonas Aeruginosa Colonization

To join this study, you need to be at least 12 years old and weigh at least 35 kilograms. You must have a diagnosis of bronchiectasis that has been confirmed by a scan of your chest. A key part of the study is for people who have been living with the Pseudomonas aeruginosa infection in their lungs, meaning it's been found in your airways at least once in the last two years and again recently.

Your bronchiectasis should be stable when you join, meaning you haven't had a flare-up requiring antibiotics for at least four weeks. You should also be receiving the usual care for your bronchiectasis and have experienced at least two moderate flare-ups or one severe flare-up needing antibiotics in the past year. Your lung function, measured by a breathing test, needs to be at a certain level.

There are some reasons why you might not be able to join. For example, if you have other main lung conditions apart from bronchiectasis, or if you have active tuberculosis or certain fungal infections in your lungs that are being treated. Generally, if you need long-term oxygen therapy for breathlessness, you wouldn't be able to participate, though using oxygen for activity is usually fine. You also can't have certain serious illnesses like active cancer.

If you decide to join this study, you would receive the study medicine, AZD0292, or a placebo (a dummy medicine), given directly into a vein (intravenously). This would happen at certain times throughout the study. You would have regular visits to the study clinic where the research team would check your health, do physical exams, and take blood and urine samples. You'd also have breathing tests, and your sputum (phlegm) would be checked regularly to see if the Pseudomonas aeruginosa infection is present. You would be asked to keep track of your symptoms and any changes in your health in a diary. These visits help the researchers understand how the medicine is working and whether it's safe. The study will last for a specific period, and more details on the exact number and timing of visits would be explained fully by the study team.