A Phase 3 Efficacy and Safety Study of Fosmanogepix for the Treatment of Adult Participants With Candidemia and/or Invasive Candidiasis.

You might be able to join this study if you are 18 years old or older and have been diagnosed with candidemia or invasive candidiasis within the last four days. It's important that your doctors can manage the source of your infection, for example, by removing any infected tubes or lines. Before joining, you or a legal guardian must also understand and agree to the study procedures.

However, there are reasons why you might not be able to take part. For instance, if your infection is caused by a specific type of Candida (Candida krusei) or certain deep-seated infections. You also wouldn't be able to join if your doctors think you have less than three days to live, or if you need kidney dialysis or similar treatments. Certain ongoing brain conditions, some HIV infections, or other serious health problems that might make taking part risky would also mean you can't join.

If you decide to take part in this study, you will be given either the new study medicine, Fosmanogepix, or one of the standard treatments for the infection. This will be decided by chance, like flipping a coin. Two out of three people will receive Fosmanogepix, and one out of three will receive a standard treatment (Caspofungin followed by Fluconazole).

Initially, both the study medicine and the standard treatments are given directly into a vein in your arm every day. This will usually happen at the hospital or clinic. If you get better and are well enough to go home, you might then switch to taking the medicine as tablets or capsules by mouth each day. You'll take these either at home or at the clinic, depending on your health.

The treatment will continue for up to six weeks, or until your infection has cleared up and your other symptoms have improved. Throughout this time, you'll have regular visits and checks to see how you're doing and if the treatment is working. After you finish the treatment, there will be one follow-up visit about six weeks later to check on your recovery. The total number of visits and the exact length of your participation will depend on how long your infection takes to clear.