Active not recruitingOBSERVATIONAL

CARdiomyopathy in Type 2 DIAbetes Mellitus

This research, called the CARDIATEAM study, wants to learn more about a heart condition known as diabetic cardiomyopathy (DCM), which can affect people with Type 2 Diabetes. The main goal is to figure out what makes DCM unique compared to other types of heart problems, especially those that lead to heart failure where the heart still pumps well, but struggles to fill properly. To do this, scientists will gather lots of information—like medical history, scans of the heart, and blood tests—from 1,600 people. This group will include individuals with and without Type 2 Diabetes, covering a wide range of ages, weights, and other health factors. By looking closely at all this data, the study hopes to identify specific features of DCM and how it develops over time. This understanding could lead to better ways to diagnose and treat heart conditions in people with Type 2 Diabetes.

At a glance

Status

Active not recruiting

Sponsor

Institut National de la Santé Et de la Recherche Médicale, France

Enrolment target

1,256

Start

02 Oct 2020

Estimated completion

01 Apr 2028

Cardiomyopathy, Diabetic

What is this study about?

Imagine your heart is a pump. Sometimes, this pump can get stiff or struggle to fill with blood properly, even if it's still able to push blood out. This is a type of heart problem. When this problem is linked to Type 2 Diabetes, it's called diabetic cardiomyopathy (pronounced car-dee-oh-my-OP-ah-thee).

This study, called CARDIATEAM, is trying to understand what makes diabetic cardiomyopathy different from other heart conditions. It's like having different types of cars that all do the same job – they all drive – but they have different engines, features, and ways they perform. The researchers want to identify the unique 'engine' of diabetic cardiomyopathy. They will do this by gathering very detailed health information from people, including those with Type 2 Diabetes and those without.

By comparing these groups, looking at things like heart scans, blood test results, and general health, the study hopes to discover clear patterns. This deeper understanding could help doctors tell the difference between diabetic cardiomyopathy and other heart problems more easily. Ultimately, this could lead to better ways to predict who might develop these heart issues and how to treat them more effectively in people living with Type 2 Diabetes.

Key takeaways

Aims to understand heart problems linked to Type 2 Diabetes.
Will compare people with and without Type 2 Diabetes.
Uses detailed health information like scans and blood tests.
Hopes to improve diagnosis and treatment of heart conditions.
Doesn't involve new medications or active treatments.

Who may be eligible?

To join this study, you would generally need to be a man or woman between the ages of 40 and 80. A key requirement is that your heart's main pumping chamber (the left ventricle) must be working well, meaning it can pump out at least 50% of the blood each beat, and there shouldn't be any parts of your heart muscle that aren't moving properly, as shown on a heart scan.

Researchers will also look closely at your medical history to make sure you fit into one of the specific groups they are studying. For example, some participants will have Type 2 Diabetes, while others will not. Some might have signs or symptoms of heart failure, where the heart still pumps well but struggles to fill, while others will not have these symptoms.

It's important that you haven't had any history of serious heart problems like a heart attack, blocked arteries that have needed treatment, or significant narrowings in your heart arteries. You also need to have a clear 'window' for heart ultrasound scans, which means the images of your heart can be seen clearly.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you between 40 and 80 years old?
Has a recent heart scan shown your heart's main pump is working well (LVEF 50% or more)?
Have you never had a heart attack or treatment for blocked heart arteries?
Do you have a clear 'window' for heart ultrasound scans?
Are you able to provide a full medical history?

Answer every question to see your result.

What does participation involve?

This section was not provided in the original text, so I cannot accurately summarise it. Information about what participation involves (e.g., number of visits, tests, duration) is crucial for potential participants.

Potential risks and benefits

Participating in research studies like this can sometimes offer benefits, such as gaining a better understanding of your own health from the detailed assessments. While this study is observational (meaning you won't be given new treatments), the information gathered could help improve care for future patients. There might be minor risks associated with the tests, such as discomfort from blood draws or slight anxiety from scans, but these are generally very low. You always have the right to withdraw from the study at any time, for any reason, without it affecting your medical care.

Locations (17)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

Hopital Louis Pradel
Verified postcode
Bron, France
Cardiology Outpatient Department at Hôpital Henri Mondor.
Verified postcode
Créteil, France
Centre Hospitalier Universitaire Grenoble Alpes
Verified postcode
Grenoble, France
department of diabetology and nutrition, APHM
Verified postcode
Marseille, France
Hôpital CHU- Nantes
Verified postcode
Nantes, France
Diabetology department, Cochin Institute
Verified postcode
Paris, France
Diabetology departement, Lariboisière Hospital
Verified postcode
Paris, France
University Hospital Aachen
Verified postcode
Aachen, Germany
University Hospital Heidelberg
Verified postcode
Heidelberg, Germany
Amsterdam UMC
Verified postcode
Amsterdam, Netherlands
University Medical Center Groningen (UMCG), Cardiology/Cardio Research
Verified postcode
Groningen, Netherlands
Academisch ziekenhuis Maastricht, Cardiology
Verified postcode
Maastricht, Netherlands

Common questions

What is diabetic cardiomyopathy?

It's a heart condition that can happen to people with Type 2 Diabetes, where the heart muscle might become stiff or struggle to fill properly, even if it's pumping blood out well.

Why is this study important?

It helps us understand exactly how diabetic cardiomyopathy is different from other heart problems, which could lead to better ways to diagnose and treat it in the future.

Will I receive new medicine as part of this study?

No, this study is observational. This means researchers will gather information about your health, but you won't be given any new medications or treatments through the study itself.

Who is funding this research?

Information about funding was not provided in the study details. Often, this is covered by research grants or charities dedicated to heart health.

Will my GP be involved?

While the study won't change your usual medical care, it's always a good idea to discuss any research participation with your GP.