Project COMFORT Study- Understanding how new blood sampling devices for use at home compare with standard hospital vein blood tests

This study is looking for adults who are 18 years old or older. You can take part if you have a heart or blood vessel condition, or if you're at a higher risk of developing one. This includes conditions like high blood pressure or high cholesterol.

You need to be able to understand what the study involves and follow instructions. You should also be willing to have blood samples taken both from a vein in your arm and using the new home device.

There are some reasons you might not be able to join. For example, if you have a skin infection where the blood sample would be taken, or if you're allergic to plasters. Also, if you have another medical condition or are in another study that might affect this research, it might not be possible to take part.

The study has two parts, and you can choose if you want to join one or both.

In Part A, you'll visit the hospital once. You'll answer some questions about your health and lifestyle. Then, a nurse or doctor will take two blood samples: one from a vein in your arm (the usual way) and one using the small microsampling device on your upper arm. After this, you'll fill out a short questionnaire about your experience.

In Part B, you'll also have one hospital visit at the beginning. During this visit, you'll be shown exactly how to use the microsampling device at home. You'll then be given three kits to take home. Over the next few weeks, you'll collect three small blood samples yourself at home, making sure there's at least 7 days between each sample. You'll send each sample back to the lab using a pre-paid envelope. Afterwards, you'll complete a questionnaire about your experience. The study runs from July 2026 to July 2027.