Inhibition of Mast cell Activation in AtheroScleroTic lesions using an Anti-IgE antibody approach (MAST)
This study, called MAST, is investigating a medicine called Xolair for individuals who have narrowed arteries in their neck, a condition known as carotid artery stenosis. The main goal is to see if Xolair can reduce the activity of specific immune cells, called mast cells, found within these narrowed arteries. By calming these cells, researchers hope to understand if it could help stop the arteries from getting worse and reduce the risk of related health issues. Participants will receive either Xolair or a dummy treatment, and doctors will check various things about their immune system and artery health. This research aims to find new ways to improve treatment for artery problems.
At a glance
What is this study about?
This research study, called MAST, is looking into how a medicine called Xolair might help people who have a condition where the arteries in their neck are narrowed. These arteries, called carotid arteries, supply blood to your brain. When they get clogged or narrowed, it can be serious.
The study focuses on a specific type of cell in your body's defence system, called mast cells. These cells can sometimes become overactive and contribute to problems in your arteries. Xolair is a medicine that works by calming down these mast cells. Researchers want to find out if giving Xolair can reduce the activity of these cells in the narrowed parts of the arteries.
By understanding if Xolair can quieten these mast cells, the study hopes to discover new ways to treat narrowed arteries and potentially prevent further complications related to this condition. This could lead to better health outcomes for people affected by carotid artery stenosis.
Key takeaways
- The study investigates Xolair for narrowed neck arteries (carotid artery stenosis).
- It aims to see if Xolair can reduce mast cell activity in these arteries.
- Participation involves receiving either Xolair or a dummy treatment.
- Various blood tests and artery assessments will be performed.
- The research hopes to find new treatment approaches for artery problems.
Who may be eligible?
To be considered for this study, you must be at least 18 years old. The study is open to both men and women.
Beyond these basic requirements, the research team will have specific medical criteria to ensure the study is safe and appropriate for you. For example, they'll check details about your carotid artery condition.
It's important to discuss your full medical history with the study doctor, who can determine if you meet all the necessary requirements to take part.
- Are you 18 years old or older?
- Are you eligible to take part, regardless of whether you are male or female?
- Do you have a diagnosis of carotid artery stenosis (narrowed neck arteries)?
- Are you able to attend regular appointments for tests and treatment?
This is a guide only — the research team will confirm whether you can take part.
What does participation involve?
If you decide to participate, you will receive either the study medicine, Xolair, or a harmless dummy treatment, given as an injection. The study team will regularly take blood samples to measure different markers related to your immune system and inflammation. They will also assess your artery health and may perform tests like scans or procedures to look at the cells in your arteries if you are already having surgery.
You'll have scheduled appointments at the study clinic for these tests and to check on your general health. The total length of your involvement in the study will be decided by the researchers, but you'll be told this clearly upfront.
Potential risks and benefits
Locations (1)
- —Netherlands
Common questions
What is 'carotid artery stenosis'?
It's when the main arteries in your neck that supply blood to your brain become narrowed, often due to a build-up of fatty deposits.
What is Xolair?
Xolair is a medicine that helps calm down certain immune cells in your body. It's often used for conditions like asthma and chronic hives.
Will I definitely get the active medicine?
Participants will be randomly assigned to receive either Xolair or a placebo (a dummy treatment) to fairly compare their effects.
What are mast cells?
Mast cells are a type of immune cell that plays a role in allergic reactions and inflammation. Researchers are studying their role in artery problems.
How long will I be in the study?
The study team will tell you the exact duration of your participation, including how many visits and assessments you will have.
How to find out more
Always speak to your GP or specialist before deciding to take part in a study.
Discussion
Community discussion
Powered by our forum at community.patient.info. Please be respectful — this is not medical advice.