Not yet recruitingOBSERVATIONAL

CMR-derived Quantitative Perfusion for Prediction of FFR

This study investigates a new method using MRI scans to measure blood flow in the heart. It's for people who have ongoing issues with their heart arteries, known as chronic coronary syndrome. The researchers want to see if this special MRI test, called quantitative perfusion, can accurately predict how well blood is flowing and identify any significant blockages. They will compare these MRI results with those from a more invasive procedure called a coronary angiogram, which is a standard way to check heart arteries. The goal is to find out if this non-invasive MRI scan could become a useful tool for diagnosing and managing heart conditions in the future, helping doctors make better decisions about treatment.

At a glance

Status

Not yet recruiting

Sponsor

Kerckhoff Klinik

Enrolment target

200

Start

01 Jul 2025

Estimated completion

30 Sep 2026

Chronic Coronary Syndrome

What is this study about?

This research study is looking into a new way to understand blood flow in the heart. Many people in the UK live with what's called 'chronic coronary syndrome,' which means they have ongoing problems with the blood vessels (arteries) that supply their heart. This can lead to symptoms like chest pain or breathlessness.

Currently, doctors often use a procedure called an angiogram to get a detailed look at these arteries and measure how well blood is flowing. This involves a thin tube being inserted into a blood vessel, usually in the arm or leg, and guided to the heart. It's a common and effective method, but it is an invasive procedure.

In this study, researchers are exploring if a special type of MRI scan, called 'quantitative perfusion,' can give doctors similar important information about heart blood flow, but in a non-invasive way. They will compare the detailed information from this MRI scan with the results from the standard angiogram to see if the MRI can accurately predict how blood is moving through the heart's arteries and even within the tiniest blood vessels. The hope is that this MRI scan could provide a safer, less invasive option for assessing heart conditions in the future.

Key takeaways

This study compares a special heart MRI with a standard heart angiogram.
It aims to see if the MRI can help predict heart artery issues.
It's for adults with ongoing heart artery problems.
Participation involves these two common heart tests.
You can stop participating at any point.

Who may be eligible?

To be part of this study, you need to be an adult, at least 18 years old. You also need to have a reason to either have a special heart MRI scan or an angiogram as part of your regular medical care. It's important that you are able to understand what the study involves and agree to take part.

However, there are some reasons why you wouldn't be able to join. For example, if you are pregnant or if you are unable to follow the study instructions. Also, if you have certain medical conditions or devices that aren't safe for an MRI scan, such as a pacemaker that isn't MRI-compatible or very severe kidney disease, you wouldn't be able to participate. If you have severe allergies to medications that might be used in the study, that would also exclude you.

Overall, the study is open to most adults who are already having certain heart tests done and don't have particular medical issues that would make participation risky or unsuitable.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Are you already scheduled for a heart MRI or angiogram?
Do you feel you understand what the study involves?
Do you NOT have a pacemaker/implant that's unsafe for MRI?
Are you NOT pregnant?
Do you NOT have very severe kidney disease?

Answer every question to see your result.

What does participation involve?

If you decide to take part in this study, you will undergo a special heart MRI scan. This scan uses special techniques to measure blood flow in your heart. You will also have a standard heart angiogram, which is a common procedure where doctors look at your heart arteries. The study involves these two key tests, which you might already be scheduled for as part of your normal care. There are no additional medications specifically for this study that you wouldn't otherwise be getting, and no long-term follow-up beyond the tests themselves. The total duration of your involvement will be based on when these two tests are completed.

Potential risks and benefits

Taking part in this study might offer a benefit by helping to advance medical understanding of heart conditions, potentially leading to better diagnostic tools for others in the future. As for direct benefits to you, you will receive standard medical care for your condition, and the study doesn't involve experimental treatments. There are some risks associated with both MRI scans and angiograms, though these are typically small and your medical team will discuss them with you. These risks are generally related to the procedures themselves, which you might be having anyway. Remember, you can choose to leave the study at any time without affecting your medical care.

Locations (1)

Kerckhoff Klinik
Verified postcode
Bad Nauheim, Germany

Common questions

What is an MRI scan?

An MRI scan uses strong magnets and radio waves to create detailed pictures of organs and structures inside your body, including your heart.

What is an angiogram?

An angiogram is a procedure where a doctor inserts a thin, flexible tube into a blood vessel to view the arteries of your heart and check for blockages.

Will I receive any new treatment?

No, this study is about comparing diagnostic tests, not new treatments. You will receive the usual care for your heart condition.

How long will my involvement last?

Your involvement in the study will mostly involve attending the scheduled MRI and angiogram appointments, which you might already have.

Can I change my mind after joining?

Yes, you are free to withdraw from the study at any time, and your decision will not affect your medical care.

How to find out more

Sören Jan Backhaus, MD

s.backhaus@kerckhoff-klinik.de 06032-996-2620 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.