Not yet recruitingNAINTERVENTIONAL

Phenotyping of Type 2 Inflammation Profile by Rheology of Nasal Secretions and Tissue Quantification of Eosinophilic Polymorphonuclear Cells in the Middle Turbinate

This study is investigating a common nose problem called Chronic Rhinosinusitis with Nasal Polyps (CRSwNP), which causes ongoing stuffiness and growths in the nose. We're comparing people with this condition to those who don't have it. The main goal is to check how thick their snot is and see if this tells us more about the type of inflammation they have. We also look at tiny cells in nose tissue and blood samples. The hope is to find a quick, simple test that helps doctors understand each patient's specific type of CRSwNP better. This could lead to more personalised and effective treatments, especially new medicines called biological treatments, helping patients feel better faster.

At a glance

Status

Not yet recruiting

Phase

Sponsor

University Hospital, Montpellier

Enrolment target

Start

01 Aug 2026

Estimated completion

01 May 2028

Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)

What is this study about?

Imagine your nose feels constantly blocked, you can't smell well, and you might have growths inside called polyps. This condition is called Chronic Rhinosinusitis with Nasal Polyps (CRSwNP). It's caused by long-term inflammation, a bit like your body's immune system overreacting.

This study is trying to find a simpler way to understand *why* some people get this condition and what kind of inflammation is happening. We know that in many cases, a specific type of inflammation, called 'Type 2' inflammation, is involved. Currently, figuring this out can involve lots of tests. What if we could use something as simple as checking how thick your snot is?

By carefully looking at nasal secretions (snot) and other samples, we hope to find a quick and easy test that doctors can use in the future. This would help them understand your specific condition better and choose the best new treatments, often called 'biological therapies', which are tailored to your body's exact needs. The ultimate goal is to help you get the right treatment faster and more effectively.

Key takeaways

This study aims to discover better ways to understand and treat chronic nose problems with polyps.
It involves collecting nasal mucus, a small tissue sample, and a blood sample during your already planned nose surgery.
The goal is to find a quick and easy test to help doctors choose personalised treatments.
You won't take new medicines or have extra visits for this study.
Participation will not directly benefit you, but could help many others in the future.
You can stop participating at any time without affecting your medical care.

Who may be eligible?

This study is looking for adults aged 18 to 85 who are already having nose surgery at a specific hospital. There are two main groups of people we are looking for.

One group is for people who have been diagnosed with chronic rhinosinusitis with nasal polyps (CRSwNP). This means you've had symptoms like a blocked or runny nose, face pain or pressure, or a lost sense of smell for at least 12 weeks, and doctors can see polyps in both sides of your nose.

We cannot include you if you have certain other conditions that can cause nasal polyps, such as cystic fibrosis, or if you are unable to provide a snot sample by blowing. You also can't take part if you are involved in another study, don't have social security, or are unable to give your full consent.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you between 18 and 85 years old?
Are you already scheduled for nose surgery at Montpellier University Hospital?
Do you have ongoing symptoms like a stuffy nose or lost sense of smell, and have polyps in your nose (if you have CRSwNP)?
Can you provide a snot sample by blowing your nose?
Do you not have other specific conditions that cause nasal polyps (like cystic fibrosis)?
Are you able to provide consent and are not in another research study?

Answer every question to see your result.

What does participation involve?

If you decide to take part in this study, here’s what would happen:

During your planned nose surgery, the doctors would collect some extra samples. This includes asking you to blow your nose onto a special plate to collect some nasal secretions (snot). They will also take a very small extra tissue sample from inside your nose (from the 'middle turbinate') during the surgery itself. In addition, a small blood sample (about 7ml, like a few teaspoons) would be taken.

This study does not involve any additional visits specifically for the research. All samples are collected around the time of your surgery. There are no new medications to take as part of this study. The total duration of your participation would be limited to the collection of these samples around your surgery time. You would continue with your regular post-surgery care as advised by your doctors.

Potential risks and benefits

Taking part in this study won't directly improve your health, but the information we gather could help future patients get better, more personalised treatments for their nose condition. The risks are very small, mainly from the extra tissue sample taken during surgery, which is a tiny piece and done while you're already having the operation. There's also the blood draw, which carries the usual small risks like slight bruising. Remember, you can choose to stop being part of the study at any time, without it affecting your medical care.

Locations (1)

University hospital Montpellier
Verified postcode
Montpellier, France

Common questions

What is CRSwNP?

It's a long-lasting condition where your nose feels blocked, you might lose your sense of smell, and you have growths called polyps inside your nose. This study is for people who have it.

Will I have to take new medicines?

No, this study doesn't involve taking any new medications. It's only about collecting samples during your planned surgery.

How long will I be in the study?

Your participation is mainly focused on the collection of samples around the time of your surgery. There are no extra follow-up visits just for the study.

Will this study help me directly?

While it won't directly change your treatment, the study aims to find better ways to understand and treat CRSwNP in the future, which could benefit others.

What do you mean by checking my 'snot'?

Researchers will gently collect a sample of your nasal mucus by asking you to blow your nose. They'll then measure how thick and sticky it is to learn more about your inflammation.

How to find out more

Valentin Favier, MD

v-favier@chu-montpellier.fr 04 67 33 67 33 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.