Ongoing, recruitingHuman Pharmacology (Phase I)- OtherInterventional

A Study to Learn How Different Amounts of the Study Medicine Called PF-07940369 are Tolerated and Act in the Body in Healthy Adults

This study is trying to understand a new medicine called PF-07940369. Researchers are giving different amounts of this medicine to healthy adult volunteers to see how it affects their bodies and how well they tolerate it. This is an early-stage study, meant to gather basic information about the medicine. The aim is to learn more about a condition called clonal hematopoiesis, which is a change in blood cell production that can happen as people get older. By studying this new medicine, scientists hope to find ways to help people in the future. Participants will be healthy adults aged 18 and over.

At a glance

Status

Ongoing, recruiting

Phase

Human Pharmacology (Phase I)- Other

Sponsor

Pfizer Inc.

Enrolment target

Start

02 Jul 2025

Clonal hematopoiesis

What is this study about?

This study is focused on a new medicine, called PF-07940369. It's an early-stage study, which means it’s one of the first times this medicine is being given to people. The main goals are to find out if the medicine is safe, how much of it the body can handle, and how it works once it's inside the body. This helps researchers understand the medicine better before it can be given to patients who might need it.

Researchers are particularly interested in how this medicine might affect a condition called 'clonal hematopoiesis'. This is a change in how blood cells are made that can happen naturally as people age. Sometimes, these changes can be linked to other health problems later on. By understanding how this new medicine works, scientists hope to learn more about clonal hematopoiesis and potentially develop new ways to manage or prevent related issues in the future.

Taking part in this kind of study a really important step in developing new treatments. It helps scientists gather essential information that can lead to making new medicines available to people who need them. Think of it as laying the groundwork for future medical advances.

Key takeaways

This study is testing a new medicine called PF-07940369.
It's an early-stage study focusing on safety and how the medicine works.
Healthy adults, aged 18 and over, are needed for the study.
Both men and women can participate.
The study aims to contribute to understanding a condition called clonal hematopoiesis.
Participation helps advance medical science for potential future treatments.

Who may be eligible?

To join this study, participants needs to be healthy adults. This means you must be at least 18 years old. There is no upper age limit, so adults of any age can be considered.

Both men and women are welcome to take part in this study. The researchers want to include a diverse group of people to get the most complete picture of how the medicine works.

Because this is an early-stage study for a new medicine, the researchers will carefully check if you are healthy enough to participate. They will look at your overall health to make sure it's safe for you to take part.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Are you generally in good health?
Are you comfortable with attending multiple clinic visits?
Are you willing to take a new, experimental medicine?
Are you able to ask questions and understand the study details?

Answer every question to see your result.

What does participation involve?

If you decide to take part in this study, you would first have a screening visit to check if you are suitable. If you are, you would then receive different amounts of the study medicine, PF-07940369. The study involves regular visits to the clinic, where doctors and nurses will monitor your health and how the medicine is affecting you. They might take blood samples, measure your vital signs (like blood pressure and heart rate), and ask you how you are feeling. The total time you would be involved in the study, including all visits and follow-ups, would be explained to you in detail before you make any decisions.

Potential risks and benefits

Participating in a research study like this offers the benefit of contributing to medical science and helping to develop potential new treatments. It's important to remember that there are no direct health benefits to you personally, as this is an early study primarily focused on understanding the medicine. All medicines carry potential risks, such as side effects, which will be fully explained to you. You will be closely monitored, and you have the right to withdraw from the study at any time, for any reason, without it affecting your medical care.

Locations (1)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

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Unverified
Belgium

Common questions

What is 'clonal hematopoiesis'?

It's a change in how your blood cells are made, which can happen with age. This study aims to learn more about it through new medicine research.

Will I get paid to participate?

This information isn't provided here, but if you're interested, this is a good question to ask the study team directly.

What does 'early-stage study' mean?

It means this is one of the first times this new medicine is being given to people, mainly to check its safety and how it works in the body.

How long will the study last if I join?

The exact duration isn't specified here, but the study team will provide you with all the details about the time commitment involved if you consider participating.

Do I have to be sick to join?

No, this particular study is looking for healthy adults to participate so they can understand how the new medicine works in people without existing health problems.