Not yet recruitingNAINTERVENTIONAL

International Study on Treatment of Patients With Metastatic Colorectal Liver Lesions Patients With IRE

This study is investigating a treatment called Irreversible Electroporation (IRE) for people with bowel cancer that has spread to their liver. This treatment uses electrical pulses to destroy cancer cells. Researchers want to gather information on how this procedure works in patients who have already received at least one course of chemotherapy. Before being considered for this study, a team of specialists will assess if IRE is a suitable treatment option for you. The study aims to understand the practical details and results of using IRE for these specific liver tumours in adults.

At a glance

Status

Not yet recruiting

Phase

Sponsor

Angiodynamics, Inc.

Enrolment target

Start

01 Feb 2026

Estimated completion

01 Feb 2029

Colorectal Adenocarcinoma Metastatic in the Liver Liver Ablation Liver Cancer, Adult

What is this study about?

This study is about a treatment called Irreversible Electroporation (IRE) for liver tumours caused by bowel cancer. When bowel cancer spreads, it often goes to the liver. IRE is a way to treat these tumours using strong but very quick electrical pulses. These pulses create tiny holes in the cancer cells, which eventually cause the cells to die. It's a precise treatment that aims to target the cancer while causing less damage to the healthy liver tissue nearby compared to some other treatments.

Researchers are focusing on patients who have already had chemotherapy for their bowel cancer. They want to collect information about how the IRE procedure is done, how effective it is, and what the recovery is like for these patients. This helps them understand more about how IRE can best be used to treat liver tumours.

This type of study is important because it helps doctors learn more about new and existing treatments. By gathering detailed information in a structured way, they can improve how they treat patients in the future and make sure patients receive the most suitable care. It's about finding better ways to manage bowel cancer when it has spread to the liver.

Key takeaways

This study is for adults with bowel cancer that has spread to the liver.
It investigates a treatment called Irreversible Electroporation (IRE).
You must have already received chemotherapy.
A team of specialists will decide if IRE is right for you.
Small liver tumours are a key requirement for joining.
Certain heart or other health conditions may prevent participation.

Who may be eligible?

To be able to join this study, you need to be at least 18 years old and have a confirmed diagnosis of bowel cancer. The cancer must have spread to your liver, and your doctors must have confirmed these liver spots are from your bowel cancer. If you have up to four small tumours (not bigger than 4cm) in your liver, or up to two if you've already had liver surgery or are having other parts of your liver removed, you might be suitable. You must also have already received at least one course of chemotherapy.

There are some reasons why you might not be able to join. For example, if you've had this type of liver treatment before, or if your tumours are larger than 4cm. If the cancer has spread to many other parts of your body, like your bones or the lining of your tummy, or you have more than two lung tumours, you might not be able to take part. Also, certain heart conditions, like having a pacemaker, or issues with your blood clotting or liver function (like jaundice), could mean you can't participate. You also can't be pregnant.

Quick self-check

Are you 18 years or older?
Do you have bowel cancer that has spread to your liver?
Have you already had at least one course of chemotherapy?
Are your liver tumours generally small (usually under 4cm)?
Do you have good overall fitness and normal blood test results for your liver and kidneys?
Do you NOT have a pacemaker or a history of serious heart rhythm problems?

This is a guide only — the research team will confirm whether you can take part.

What does participation involve?

The study involves having the Irreversible Electroporation (IRE) procedure to treat your liver tumours. Before the procedure, your medical team will record information about your health and the details of your cancer. During the procedure, specific details about how the IRE is performed will be noted. After the procedure, your doctors will monitor your recovery and how the treatment has worked. There aren't any specific details provided about extra visits or follow-up beyond what would usually be part of your care after such a procedure. The total duration of your participation isn't specified, but it would involve the preparation for, the procedure itself, and ongoing follow-up as part of your standard medical care.

Potential risks and benefits

Potential benefits of taking part in this study include receiving Irreversible Electroporation (IRE), which could help control your liver tumours. This treatment aims to destroy cancer cells with potentially less damage to surrounding healthy tissue. As with any medical procedure, there are potential risks, which your doctor will explain in detail. These can include side effects from the procedure itself. Remember, you have the right to withdraw from the study at any time, for any reason, without it affecting your future medical care.

Locations (1)

Manchester Royal Infirmiary
Manchester, United Kingdom

Common questions

What is Irreversible Electroporation (IRE)?

IRE is a treatment that uses electrical pulses to destroy cancer cells, particularly in the liver, while trying to protect nearby healthy tissues.

Do I need to have had chemotherapy already?

Yes, to be considered for this study, you must have already finished at least one round of chemotherapy for your bowel cancer.

What if my tumours are large?

If individual tumours are larger than 4cm, you would not be able to join this specific study.

Can I join if I have a pacemaker?

No, if you have a pacemaker or some other heart conditions, you would not be able to take part in this study.

What if my cancer has spread to other parts of my body?

If your cancer has spread widely to many different parts, like bones or large areas of your lungs, you might not be eligible for this study.

How to find out more

Mitchell Vanderpoll

mvanderpoll@angiodynamics.com +44 7790921819 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.