RecruitingOBSERVATIONAL

Molecular Characterisation of Colorectal Cancer Peritoneal Metastases

This UK-based study investigates bowel cancer that has spread to the lining of the abdomen, known as peritoneal metastases. Researchers will analyse existing tissue samples from patients who have already had surgery. The aim is to understand the genetic changes in these cancers and how they interact with their surroundings. By doing this, the study hopes to find new ways to predict how these cancers will behave and discover better, more personalised treatment options. Ultimately, this research aims to improve the quality of life and survival for patients with this type of advanced bowel cancer.

At a glance

Status

Recruiting

Sponsor

The Christie NHS Foundation Trust

Enrolment target

200

Start

04 Feb 2024

Estimated completion

03 Jul 2025

Colorectal Cancer Metastatic

What is this study about?

This study focuses on bowel cancer that has spread to the peritoneum, which is the lining of the tummy area. This type of spread, called peritoneal metastases, is a serious condition that can cause difficult symptoms and shorten a person's life. While surgery is often used, it's a major operation. Doctors want to understand why some bowel cancers spread to the peritoneum and how these cancer cells change over time.

To do this, researchers will be looking at tissue samples that have already been collected from patients who previously had surgery for bowel cancer that had spread to their peritoneum. They'll be using advanced lab techniques to study the genetic makeup of these cancer cells. By comparing the genes in the original bowel cancer with those in the spread, they hope to identify specific features that could help predict how the cancer will respond to treatment or how long someone might live.

The ultimate goal of this research is to pave the way for more effective and personalised treatments. By gaining a better understanding of these cancers, doctors might be able to select the best treatment for each individual patient, potentially leading to a better quality of life and helping people live longer.

Key takeaways

Looks at bowel cancer spread to the tummy lining.
Uses existing stored tissue samples and medical records only.
Aims to understand why cancer spreads and how it changes.
Hopes to find new biomarkers and better treatment strategies.
Could lead to personalised treatment options for future patients.
No direct patient involvement or hospital visits needed.

Who may be eligible?

To be included in this study, participants must be at least 18 years old and have been diagnosed with bowel cancer that has spread to the lining of the abdomen (peritoneal metastases).

Additionally, they must have had a specific type of surgery called "cytoreductive surgery" at The Christie hospital. Researchers also need to have stored tissue samples available from both their original bowel cancer and the spread to the peritoneum.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Have you been diagnosed with bowel cancer that spread to your tummy lining?
Did you have surgery for this at The Christie hospital?
Were tissue samples (from your original cancer and the spread) collected and stored?

Answer every question to see your result.

What does participation involve?

If you meet the criteria, you would not need to do anything extra. This study involves looking at existing tissue samples and medical records from patients who have already undergone surgery. There are no study visits, new assessments, medication, or follow-up required from participants directly. Your involvement is indirect, through the use of your pre-existing data and stored tissue.

Potential risks and benefits

This study uses existing data and stored tissue samples, meaning there are no direct physical risks to participants. The potential benefits include contributing to a better understanding of bowel cancer spread, which could lead to improved treatments and outcomes for future patients. You have the right to withdraw your consent for the use of your data and tissue at any time, without affecting your current or future medical care.

Locations (1)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

Christie Hospital NHS Foundation Trust
Verified postcode
Manchester, United Kingdom· Recruiting

Common questions

What is peritoneal metastases?

It's when bowel cancer cells spread to the lining of your abdomen, also known as the peritoneum.

What kind of cancer is being studied?

This study is about bowel (colorectal) cancer that has spread to the lining of the abdomen.

Will I need to go to the hospital for this study?

No, this study uses existing stored tissue samples and medical records. You won't need any hospital visits or appointments.

What will researchers do with my tissue samples?

They will examine the genetic makeup of the cancer cells to understand how they change and spread.

How will this study help patients?

It aims to find better ways to predict how cancer behaves and to develop more personalised and effective treatments in the future.

How to find out more

Richa Garvia, Ms

removed_due_to_spam@email.com 0161 446 3000 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.