Investigating Epstein-Barr Virus Associated Conjunctivitis
This study is investigating a common eye condition called conjunctivitis, also known as pink eye. It happens when the clear lining of your eye gets inflamed. While often caused by cold viruses and usually gets better on its own, researchers at Moorfields Eye Hospital have noticed that another very common virus, Epstein-Barr virus (EBV), is sometimes found in people with conjunctivitis. Most adults have had EBV, often as glandular fever, but sometimes it can reactivate without obvious symptoms. The study aims to find out if this reactivated EBV might be causing some cases of conjunctivitis. Better understanding could lead to improved diagnosis and treatment for patients.
At a glance
What is this study about?
Conjunctivitis, often called 'pink eye,' is when the thin, see-through layer covering the white part of your eye and the inside of your eyelids becomes red and swollen. It's a very common eye problem that often sends people to emergency departments or their GP.
Usually, when germs cause conjunctivitis, it's due to a common cold virus called adenovirus, and it tends to get better by itself without needing special treatment. However, doctors at Moorfields Eye Hospital have found that another virus, Epstein-Barr virus (EBV), is sometimes also present in the eyes of people with conjunctivitis. Most adults (about 95%) have had EBV, often causing mild symptoms or 'glandular fever' when they were younger. Once you've had it, EBV stays in your body but usually doesn't cause problems.
Occasionally, EBV can 'wake up' or reactivate, though most people don't even notice. The researchers think that this reactivated EBV might be causing some cases of conjunctivitis. By studying this further with the help of University College London, they hope to get a clearer picture of how various infections lead to conjunctivitis. This improved knowledge could lead to better ways to help people with this eye condition.
Key takeaways
- The study explores if the common EBV virus causes some cases of pink eye.
- It aims to improve understanding and treatment of conjunctivitis.
- Participation involves eye swabs, a blood test, and a small eyelid tissue sample.
- Most adults have already had EBV, often without knowing.
- Improved knowledge could help future patients with eye inflammation.
Who may be eligible?
To be part of this study, you need to be at least 16 years old. You would also have been diagnosed with an 'infective follicular conjunctivitis' (a type of pink eye caused by an infection) that started less than four weeks ago, and a previous test must have shown that you have Epstein-Barr virus (EBV) in your eye.
However, you wouldn't be able to join if your doctor thinks your eye problem is more likely due to something else, like a reaction to eye drops. Also, if you can't have the necessary samples taken from your eye for any reason, you wouldn't be able to participate. This study is open to both men and women.
Could this study suit you?
Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.
- Are you 16 years old or older?
- Have you been diagnosed with an eye infection (viral conjunctivitis) that started less than 4 weeks ago?
- Has a test already shown that EBV is present in your eye?
- Does your doctor agree that this study is suitable for you?
- Are you able to have samples taken from your eye (swab, tissue) and blood?
What does participation involve?
If you decide to take part, the researchers will need to collect a few samples. This will involve taking a swab from the surface of your eye (like a gentle wipe), a single blood sample (like a routine blood test), and a tiny sample (about 1-2mm) from the inside of your eyelid. The study does not involve taking any new medications. The total duration of your participation would depend on how quickly these samples can be collected. There isn't a specific follow-up schedule mentioned, but the focus is on gathering information at the time of your eye condition.
Potential risks and benefits
Locations (1)
- Moorfields Eye Hospital NHS Foundation TrustVerified postcodeLondon, United Kingdom
Common questions
What is conjunctivitis?
Conjunctivitis, also known as 'pink eye,' is when the clear lining of your eye and eyelid gets red and swollen.
What is Epstein-Barr virus (EBV)?
EBV is a very common virus, most adults have had it, often causing glandular fever. It then stays in your body, usually without causing problems.
Why are you studying EBV and conjunctivitis?
Researchers have found EBV in some people with conjunctivitis and want to see if it might be causing the eye inflammation.
What does taking part involve?
It involves a gentle eye swab, a blood test, and a tiny tissue sample from your inner eyelid.
Will I get new medicine?
No, this study is about understanding the cause of conjunctivitis, not testing new medications.
How to find out more
Always speak to your GP or specialist before deciding to take part in a study.
Interested in taking part?
Discussion
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