All studies
RecruitingNAINTERVENTIONAL

Improved Management of Patients With Recent-Onset Stable Chest Pain

This German study is looking for better ways to check for heart problems in people with ongoing chest pain. Currently, many people have a procedure called a cardiac catheterisation, but there's a less invasive option: a special heart scan called a coronary CT. This study will test a new healthcare approach across 16 regions to see if using the CT scan more often, as guidelines suggest, can improve care. Researchers want to know if this new approach helps prevent serious heart issues like heart attacks and strokes, and if it saves money for the healthcare system. If it works well, this new system could be used across Germany to give patients better care and avoid unnecessary procedures and costs.

At a glance

Status
Recruiting
Phase
NA
Sponsor
Philipps University Marburg
Enrolment target
3,369
Start
01 Apr 2026
Estimated completion
01 Mar 2028

What is this study about?

When you have chest pain, doctors often need to find out if there's a problem with the blood vessels that supply your heart. This is called Coronary Artery Disease (CAD) and it's a very common health issue. In Germany, a common way to check for this has been a procedure called cardiac catheterisation, where a thin tube is put into a blood vessel and guided to the heart. However, there's another diagnostic tool called a coronary CT scan (a special kind of X-ray) that can also show if there are blockages in these heart vessels. It's often less invasive and has fewer risks.

This study, called IMPRO, wants to see if using the coronary CT scan more often, especially when guidelines suggest it, can improve how doctors identify and manage suspected heart conditions in people with stable chest pain. They are testing a new care model across different regions in Germany. The main goal is to find out if this new approach helps to reduce serious heart problems like heart attacks and strokes in patients. They also want to understand how patients feel about this type of care and if it helps save money for the healthcare system.

The researchers believe that if this new way of working is successful, it could be rolled out across the whole of Germany. This would mean that patients with suspected heart disease get the most appropriate and effective diagnosis, potentially avoiding more invasive procedures when they aren't needed. Ultimately, it aims to improve the quality of care for a large number of people while also making the healthcare system more efficient.

Key takeaways

  • This study in Germany explores a new approach to managing stable chest pain.
  • It focuses on using coronary CT scans more effectively to diagnose heart conditions.
  • The goal is to improve patient care, reduce serious heart events, and lower healthcare costs.
  • It's a study about how care is organised, not testing a new drug.
  • If successful, this new care model could be used across Germany.

Who may be eligible?

To be considered for this study, you need to be at least 30 years old and experiencing chest pain that doctors suspect could be related to Coronary Artery Disease (CAD). It’s important that this chest pain is stable, meaning it’s not a sudden, new, or rapidly worsening pain that suggests a heart attack.

You also need to be able to fully understand what taking part in the study means and give your permission to join. The study is specifically for people with statutory health insurance in Germany.

However, you wouldn't be able to join if you already know you have serious CAD that's significantly blocking your arteries, or if you've already had treatments like a stent (PCI) or bypass surgery (CABG). Also, if you've had a recent clear heart scan (coronary angiography or CT) in the last five years, or if you're currently having a heart attack, this study might not be suitable for you.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

  1. Are you at least 30 years old?
  2. Do you have stable chest pain, possibly from a heart condition?
  3. Do you have German statutory health insurance?
  4. Have you NOT had previous treatment (like a stent or bypass) for serious heart artery blockages?
  5. Have you NOT had a clear heart scan (invasive or CT) in the last 5 years?
  6. Are you able to understand and agree to join the study?
Answer every question to see your result.

What does participation involve?

This study is testing a new way of organising care, rather than a new medicine or treatment. If you are eligible and agree to take part, you would be receiving care in a way that includes more use of coronary CT scans, as recommended by medical guidelines. The study would involve your doctors following this new care model. You would likely have follow-up appointments and tests as part of your standard care, which the study would be monitoring to see how effective this new model is in preventing heart events and managing your condition. The total duration of your involvement isn't specified, but the overall project runs for 39 months, monitoring outcomes over time.

Potential risks and benefits

Taking part in this study could potentially benefit you by ensuring you receive care that uses the most up-to-date diagnostic methods for your chest pain, potentially leading to earlier and more accurate diagnosis if you have a heart condition. For the healthcare system, it aims to improve care quality and reduce unnecessary procedures and costs. As this study mainly evaluates a new care model incorporating existing diagnostic tests, risks are generally low, focusing on the diagnostic tests themselves (like very low radiation from CT scans, which your doctor can explain). You are always free to withdraw from the study at any time without affecting your usual medical care.

Locations (39)

  • Universitätsklinikum Augsburg, Diagnostische und Interventionelle Radiologie und Neuroradiologie
    Verified postcode
    Augsburg, Germany· Recruiting
  • Universitätsklinikum Augsburg, Institut für Allgemeinmedizin
    Verified postcode
    Augsburg, Germany· Recruiting
  • RHOEN-Klinikum AG, Campus Bad Neustadt, Klinik für Radiologie
    Verified postcode
    Bad Neustadt an der Saale, Germany· Recruiting
  • Charité-Universitätsmedizin Berlin, Institut für Allgemeinmedizin
    Verified postcode
    Berlin, Germany· Recruiting
  • Charité - Universitätsmedizin Berlin, Klinik für Radiologie
    Verified postcode
    Berlin, Germany· Recruiting
  • Uniklinik Köln, Institut für Diagnostische und Interventionelle Radiologie
    Verified postcode
    Cologne, Germany· Recruiting
  • Universitätsklinikum Köln, Institut für Allgemeinmedizin
    Verified postcode
    Cologne, Germany· Recruiting
  • Universitätsklinikum Düsseldorf, Institut für Allgemeinmedizin (ifam)
    Verified postcode
    Düsseldorf, Germany· Recruiting
  • Universitätsklinikum Düsseldorf, Institut für Diagnostische und Interventionelle Radiologie
    Verified postcode
    Düsseldorf, Germany· Recruiting
  • Röntgeninstitut
    Verified postcode
    Düsseldorf, Germany· Recruiting
  • Universitätsklinikum Erlangen, Allgemeinmedizinisches Institut
    Verified postcode
    Erlangen, Germany· Recruiting
  • Universitätsklinikum Erlangen, Radiologisches Institut
    Verified postcode
    Erlangen, Germany· Recruiting

Common questions

What is Coronary Artery Disease (CAD)?

CAD is when the blood vessels that supply your heart become narrowed or blocked, which can cause chest pain and other heart problems.

What is a coronary CT scan?

It's a special X-ray scan that takes detailed pictures of your heart and the blood vessels around it to check for any blockages or narrowing.

How is this different from a cardiac catheterisation?

A CT scan is non-invasive (nothing is inserted into your body), while a cardiac catheterisation involves a thin tube being guided into your heart vessels.

Will I get a new medicine in this study?

No, this study isn't about new medications. It's about a new way doctors manage and diagnose chest pain using existing diagnostic tools like the coronary CT scan.

Who is funding this study?

The project is funded with approximately 9.3 million euros, overseen by the project partners in Germany.

How to find out more

Annika Viniol, Prof. Dr.

Always speak to your GP or specialist before deciding to take part in a study.

Interested in taking part?

Register your interest

Share your details and the research team for "Improved Management of Patients With Recent-Onset Stable Che…" will contact you if you may be eligible. Always speak to your GP before agreeing to take part.

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