Ongoing, recruitingHuman Pharmacology (Phase I)- OtherInterventional

A study to learn how PF-07817883 is taken up into the blood of healthy adults after taking tablets of study drug with varying ingredients

This early-stage study is investigating a new medication, PF-07817883, which could potentially help people with COVID-19. For now, researchers are focusing on how the drug behaves in healthy adults. They want to understand how different combinations of ingredients within the tablet affect how much of the medicine gets into the bloodstream and how quickly. This step is important for making sure the medication works as expected and can be given safely in the future. By carefully studying healthy volunteers, scientists can learn vital information before testing the medicine in people who are unwell.

At a glance

Status

Ongoing, recruiting

Phase

Human Pharmacology (Phase I)- Other

Sponsor

Pfizer Inc., Pfizer Inc.

Enrolment target

Start

13 Oct 2023

coronavirus disease 2019

What is this study about?

This study is about a new medicine called PF-07817883, which scientists hope might be able to treat COVID-19. Before they can test this medicine in people who are sick, they need to understand how it works in the body of healthy adults. Think of it like baking a cake: if you want the cake to turn out perfectly, you need to know how different ingredients affect the final result. In this study, scientists are looking at how different combinations of ingredients in the medicine's tablet form affect how the medicine gets into the blood.

Learning how the medicine is absorbed into the blood is really important. It helps scientists figure out the best way to make the tablets so that the right amount of medicine gets to where it needs to be in the body. This is a very early stage of research, which means it's one of the first steps in developing a new medicine.

By carefully studying healthy volunteers, researchers can gather important information about the drug's properties without putting people who are already unwell at risk. This helps ensure that when the medicine is eventually tested in people with COVID-19, it's more likely to be effective and safe.

Key takeaways

This study is testing a new medicine for COVID-19.
It's an early-stage study in healthy adults.
Researchers are looking at how different tablet ingredients affect absorption into the blood.
Participation helps advance potential COVID-19 treatments.
All risks and benefits will be fully explained to you.

Who may be eligible?

This study is looking for healthy adult volunteers. To take part, you need to be 18 years old or older. There is no upper age limit, meaning people of any age above 18 can be considered.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Are you generally healthy?
Do you understand that this medicine is experimental?
Are you able to attend regular study appointments?

Answer every question to see your result.

What does participation involve?

If you decide to take part, you would receive tablets of the study drug. The researchers will then take blood samples at different times to see how the medicine is absorbed into your body. This would involve regular visits to the study site for these assessments. You would also have check-ups to make sure you are staying healthy. The full duration of your participation, including all visits and follow-ups, would be explained to you before you agree to join.

Potential risks and benefits

Taking part in this study could help scientists learn important information about a potential new treatment for COVID-19. While there is no direct personal benefit to you from taking this medicine as you are healthy, your participation helps advance medical research for everyone. Like all medicines and studies, there might be some risks, such as side effects from the medication or discomfort from blood tests. All potential risks will be fully explained before you agree to participate. Remember, you have the right to withdraw from the study at any time, for any reason, without it affecting your medical care.

Locations (1)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

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Unverified
Belgium

Common questions

What is PF-07817883?

It's a new medicine being developed to potentially treat COVID-19. This study is an early step in understanding how it works.

Why is this study only for healthy adults?

Researchers want to understand how the medicine behaves in the body without other health conditions making the results unclear. This helps ensure it's safe to test in sick people later.

Will I get paid for taking part?

The study team will explain if there is any payment or reimbursement for your time and travel if you decide to participate.

Will I know if the medicine actually had an effect on me?

Since you are healthy, the main effects being measured are how the drug gets into your blood, not its treatment effects on COVID-19. You won't be given special results about the drug's action in your body, but you can ask for general study findings later.

Is this medicine available to the public?

No, this is an experimental medicine that is not yet approved for public use. It's still in the very early stages of testing.