RecruitingOBSERVATIONAL

Ocular Characteristics in Patients With Craniosynostosis

This study is gathering information about eye health in children who have craniosynostosis. Craniosynostosis happens when some of the skull bones in a baby’s head join together too soon. This can change the shape of their head and sometimes affect brain growth. About 1 in 2,500 babies are born with this condition. While for many, it's an isolated issue, for others, it's part of a broader health problem. Because craniosynostosis can also lead to eye problems like difficulties with vision, eye movement, or damage to the optic nerve, researchers at Amiens University Hospital are looking back at patient records. Their goal is to better describe and understand the types of eye issues found in these patients.

At a glance

Status

Recruiting

Sponsor

Centre Hospitalier Universitaire, Amiens

Enrolment target

Start

04 Apr 2025

Estimated completion

01 Nov 2026

Craniosynostosis Strabismus Intracranial Hypertension Amblyopia

What is this study about?

This study is designed to help us better understand the eye health of children born with a condition called craniosynostosis. Craniosynostosis happens when one or more of the bones in a baby's skull join together too early, which can affect the shape of their head. This condition occurs in about 1 in every 2,500 births. Sometimes, it's the only health issue a child has, but in about 20% of cases, it's linked to other health problems.

Beyond making the head an unusual shape, craniosynostosis can sometimes cause problems because the skull doesn't grow properly around the developing brain. It's also known that children with craniosynostosis can frequently experience various eye problems. These might include needing glasses (refractive disorders), having eyes that don't move together properly (strabismus or oculomotor disorders), damage to the nerve that connects the eye to the brain (optic nerve damage), or difficulties with how the brain processes what the eyes see (sensory damage).

The researchers at Amiens University Hospital are looking back at the medical records of patients who have been treated for craniosynostosis. By carefully reviewing these records, they hope to get a clearer picture of the different kinds of eye problems that are common in these children. This information can help doctors understand the condition better and improve how they care for future patients.

Key takeaways

This study focuses on eye health in children with craniosynostosis.
Craniosynostosis is when skull bones fuse too early, affecting head shape.
Researchers are reviewing past patient records to learn about common eye problems.
No new appointments, tests, or medication are involved for patients in this 'records-only' study.
The goal is to improve understanding and future care for children with craniosynostosis.

Who may be eligible?

This study is open to anyone of any age who has been diagnosed with craniosynostosis. This is a condition where some of the bones in the skull join together too early.

However, it's important to know that people with a specific type of head shape called 'posterior plagiocephaly' will not be included in this study. This condition, even though it also affects head shape, is different from craniosynostosis in how it develops.

Both males and females are welcome to be part of this research, as the condition affects both sexes.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Have I/my child been diagnosed with craniosynostosis?
Do I/my child have posterior plagiocephaly? (If yes, you may not be eligible)
Are eye doctors and specialists at Amiens University Hospital involved in my/my child's care?

Answer every question to see your result.

What does participation involve?

As this is a 'retrospective' study, it means that researchers will be looking back at existing medical notes and information from patients who have already been treated. You or your child would not need to attend any extra appointments, have any new tests, or take any medication specifically for this study. There wouldn't be any follow-up visits required, and the study doesn't involve any direct participation or changes to your current medical care. The researchers will simply be reviewing information that has already been collected during previous medical appointments.

Potential risks and benefits

Since this study only involves reviewing existing patient records, there are no direct physical risks to participants. Your privacy is important, and the researchers will handle all information carefully to protect your identity. The main benefit of participating (indirectly, by having your records included) is helping doctors learn more about craniosynostosis and its effects on eyesight. This could lead to better care for children with the condition in the future. You always have the right to ask for your or your child's records not to be included, even if they fit the study's criteria.

Locations (1)

CHRU Amiens
Verified postcode
Amiens, France· Recruiting

Common questions

What is craniosynostosis?

It's a condition where a baby's skull bones join together too early, which can affect head shape and sometimes brain growth.

Why are researchers looking into eye problems?

Eye issues like blurry vision or problems with how eyes move are common in children with craniosynostosis, and this study aims to understand them better.

Will I or my child need to do anything for this study?

No, this study only looks at existing medical records, so no new appointments or tests are needed.

Who is running this study?

This research is being conducted by doctors and researchers at Amiens University Hospital.

How will this study help patients?

By understanding more about eye problems in craniosynostosis, doctors hope to improve care and treatment for children with the condition in the future.

How to find out more

Tran Thi Ha Chau, Pr

tran.chau@chu-amiens.fr 33+322089224 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.