An open-label, single-center, non-controlled pilot clinical trial to assess the efficacy of weekly semaglutide in combination with regular counselling sessions to reduce craving and use of chemsex associated drugs (CoSem4Chemsex) study.
This study, called CoSem4Chemsex, is testing a medicine called semaglutide (also known as Ozempic) along with regular counselling sessions. Its main aim is to see if this combination can help people who have strong cravings for, and use, 'chemsex' drugs like cathinones, crystal methamphetamine, and GHB/GBL. The study is particularly looking at how much people's cravings go down. They will also track how much of these drugs people use, their quality of life, and any side effects from the medication. This is an early-stage study, meaning it's one of the first times this treatment is being tested for this specific purpose.
At a glance
What is this study about?
This study is looking into a new way to help people who experience strong cravings for, and use of, certain drugs. These drugs are often linked to 'chemsex', which is when drugs are used to enhance sexual experiences. The trial is called CoSem4Chemsex, and it's testing a medicine called semaglutide, which you might know as Ozempic. This medicine is given as a weekly injection.
The main idea behind this study is to see if taking semaglutide along with regular counselling can help reduce how much people crave these drugs and how often they use them. Researchers believe that semaglutide might help by affecting certain brain signals related to feeling rewarded or craving. Combining this potential physical effect with mental health support from counselling could offer a new way to help.
This is an early-stage study, sometimes called a 'Phase II' study. This means it's one of the first times this treatment is being tested for this specific problem. The researchers want to find out if it's safe enough and if it shows promise before moving on to larger studies. They will be carefully monitoring participants to understand the treatment's effects and any potential side effects.
Key takeaways
- This study is testing a weekly injection (semaglutide) plus counselling for drug cravings and use.
- It focuses on specific drugs linked to 'chemsex' (cathinones, crystal methamphetamine, GHB/GBL).
- It's an early-stage study to see if the treatment works and is safe.
- Participation involves weekly injections, counselling, and regular check-ups.
- Only men aged 18 and over are eligible for this particular study.
Who may be eligible?
To join this study, you need to be an adult, aged 18 or older. The study is specifically recruiting men.
It's important that you have experienced cravings for, and used, certain 'chemsex' drugs like cathinones, crystal methamphetamine, or GHB/GBL. The researchers will have specific criteria to make sure the study participants are a good match for what they are trying to understand.
If you're a man aged 18 or over and believe you fit this description, you might be able to take part. However, there will be other medical checks to make sure the treatment is suitable for you and that taking part would be safe.
Could this study suit you?
Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.
- Are you 18 years old or older?
- Are you a man?
- Have you experienced cravings for and used drugs like cathinones, crystal methamphetamine, or GHB/GBL?
- Are you willing to attend regular clinic visits and counselling sessions?
What does participation involve?
If you decide to take part in this study, you would receive weekly injections of an experimental drug called semaglutide. The dose might start at 0.25 mg and could increase to 0.5 mg or 1 mg over time, as guided by the study team. You would also have regular counselling sessions. The study will involve several visits to a clinic for these injections, counselling, and to answer questions about your cravings and drug use. You'll also be asked about your general health and well-being. Researchers will track your progress over time, including how your cravings change and any side effects you might experience. The total duration of your participation in the study, including all treatments and follow-up, will be explained fully by the study team.
Potential risks and benefits
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Common questions
What is semaglutide (Ozempic)?
Semaglutide is a medicine that's usually used for conditions like type 2 diabetes or weight management. In this study, we're exploring if it might also help with drug cravings.
What are 'chemsex' drugs?
These are drugs such as cathinones, crystal methamphetamine, and GHB/GBL, which are sometimes used to enhance sexual experiences.
Will I have to stop using drugs to join?
The study aims to help reduce drug use and cravings. The study team will discuss with you what this means for your participation.
Is counselling part of the study?
Yes, regular counselling sessions are a key part of this study, alongside the weekly medication.
Will my information be kept private?
Yes, all your personal and medical information will be kept strictly confidential and protected according to privacy laws.
How to find out more
Always speak to your GP or specialist before deciding to take part in a study.
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