Not yet recruitingNAINTERVENTIONAL

A Clinical Study to Assess the Efficacy of a Calcium Sodium Phosphosilicate Toothpaste for the Relief of Dentine Hypersensitivity

This research study is looking into a new toothpaste designed to help with sensitive teeth (dentin hypersensitivity). We want to find out if this special toothpaste works better at reducing sensitivity to cold air than a standard fluoride toothpaste. Participants will use either the new toothpaste or a regular fluoride toothpaste twice a day for 8 weeks. Researchers will then compare how much each group's tooth sensitivity has improved. The study is carefully designed to make sure the results are fair and reliable, involving around 192 healthy people who experience sensitive teeth. It's a way to see if this new toothpaste could offer a more effective solution for many people.

At a glance

Status

Not yet recruiting

Phase

Sponsor

HALEON

Enrolment target

192

Start

01 Sep 2026

Estimated completion

01 Mar 2027

Dentin Sensitivity

What is this study about?

Many people suffer from sensitive teeth, which can be a real nuisance when eating, drinking, or even just breathing in cold air. This happens when the soft, inner part of your tooth, called dentin, becomes exposed. This study is testing a new toothpaste that contains a special ingredient called Calcium Sodium Phosphosilicate (CSPS). The aim is to see if this special toothpaste can help reduce the discomfort of sensitive teeth more effectively than a standard fluoride toothpaste.

Imagine your teeth have tiny tubes that lead to the nerves inside. When these tubes become exposed, things like cold air can reach the nerves and cause pain. The new toothpaste being tested is designed to help block or cover these tiny tubes, hopefully reducing that uncomfortable feeling. If it works well, it could offer a new and better way for people in the UK to manage their sensitive teeth.

Taking part in this study means you would use one of the two toothpastes (either the new one or a regular fluoride one) twice a day for about 8 weeks. Throughout this time, dentists and researchers would check your teeth and ask about your sensitivity levels to see how well the toothpaste is working. This is a common way to test new treatments to make sure they are safe and effective before they are widely available.

Key takeaways

Tests a new toothpaste for sensitive teeth.
Compares it to a regular fluoride toothpaste.
Involves using toothpaste twice daily for 8 weeks.
Aims to reduce discomfort from cold air sensitivity.
Open to adults aged 18+ with sensitive teeth.
Results could help improve future treatments for sensitive teeth.

Who may be eligible?

To join this study, we're looking for adults aged 18 or older who have sensitive teeth. You should be in good general health, both physically and mentally, and have at least 20 natural teeth in your mouth. Your sensitive teeth should have been bothering you for more than six months but less than ten years.

Specifically, you need to have at least two teeth that are sensitive to cold air and touch. These teeth should be in different parts of your mouth and show some exposed areas, perhaps from brushing too hard or receding gums. The gums around these sensitive spots should be healthy, and the teeth themselves shouldn't be wobbly.

It's also important that you're happy and able to follow all the study's instructions, including attending appointments and using the toothpaste as directed. Before you start, a dentist or doctor involved in the study will check to make sure it's safe for you to take part and that you meet all the requirements.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Do you have sensitive teeth that have bothered you for more than 6 months?
Do you have at least 20 natural teeth?
Are you generally in good health?
Can you commit to attending study appointments for about 8 weeks?
Do you have at least two sensitive teeth in different areas that react to cold air or touch?

Answer every question to see your result.

What does participation involve?

If you decide to take part, you'll first have a screening visit where we check if the study is right for you. This involves answering questions about your health and a quick dental check-up to confirm your tooth sensitivity. If you qualify, you'll then have a baseline visit where your sensitivity is measured more precisely. After this, you will be given one of two toothpastes: either the special test toothpaste or a regular fluoride toothpaste.

You'll be asked to brush your teeth twice a day with the assigned toothpaste for 8 weeks. You won't know which toothpaste you're using, and neither will the researchers, to ensure the results are fair. You'll have follow-up visits during these 8 weeks to check on your sensitivity and progress. The total time you'd be involved in the study would be about 8 weeks of using the toothpaste, plus the initial screening and baseline visits.

Potential risks and benefits

Taking part in this study might help you find relief from your sensitive teeth, potentially with a new toothpaste that could be more effective. You'll also receive careful dental checks and advice during the study. As with any study, there could be some minor risks, such as temporary discomfort during sensitivity tests or an unexpected reaction to the toothpaste, though these are uncommon. All toothpastes used are common types. You are free to stop participating at any time, for any reason, without it affecting your medical care.

Locations (1)

University of Bristol Dental School
Verified postcode
Bristol, United Kingdom

Common questions

What kind of sensitive teeth are you looking for?

We are looking for people whose teeth are sensitive to cold air or touch, and this sensitivity has been present for a while, typically more than 6 months.

Will I know which toothpaste I'm using?

No, neither you nor the researchers will know whether you're using the special test toothpaste or a regular fluoride toothpaste. This helps make the study results fair.

How long will I need to use the toothpaste?

You will be asked to use the toothpaste twice a day for 8 weeks.

Do I have to pay to join the study?

No, there are no costs for taking part in the study. Any study-related toothpastes and checks will be provided.

What happens if I want to stop taking part?

You are free to leave the study at any time, for any reason. Just let the study team know.

How to find out more

Haleon Response Center

ww.clinical-trial-register@haleon.com +441932 95 95 00 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.