AuthorisedTherapeutic use (Phase IV)Interventional

Healing Diabetic Foot Ulcers with Semaglutide

This research is investigating a medicine called semaglutide, known by the brand name Ozempic, to see if it helps heal diabetic foot ulcers. Diabetic foot ulcers are open sores that can appear on the feet of people with diabetes. In this study, people will either receive semaglutide in different doses along with their typical treatment, or they will continue with only their usual treatment. The main goal is to find out how long it takes for these ulcers to close completely. Researchers will also be looking at other things like how much the ulcer shrinks, changes in blood flow in the legs, and if there are fewer serious problems like infections or amputations. This is a Phase 4 study, meaning the treatment is already approved for other uses but doctors are now studying it for this specific condition.

At a glance

Status

Authorised

Phase

Therapeutic use (Phase IV)

Sponsor

Radboud universitair medisch centrum Stichting

Enrolment target

Start

30 Mar 2026

Diabetic foot ulcer

What is this study about?

This study is looking into whether a medicine called semaglutide, which you might know as Ozempic, can help people with diabetic foot ulcers. A diabetic foot ulcer is a common problem for people with diabetes, where a wound on their foot struggles to heal properly. These ulcers can cause pain and sometimes lead to more serious health issues if not treated effectively.

The main aim of this research is to see if semaglutide, when added to the usual care a patient receives, can speed up the healing process of these ulcers. Researchers will be carefully measuring how long it takes for a wound to close completely in patients using semaglutide compared to those receiving only standard care. This will help them understand how effective semaglutide might be for this particular problem.

Beyond just healing time, the study will also look at several other important factors. This includes how much the ulcer shrinks, if there are any changes in the blood flow to the leg and foot, and if complications like infections or the need for surgery to remove part of the leg (amputation) are less common. By looking at all these things, the study hopes to get a full picture of how semaglutide might help people with diabetic foot ulcers.

Key takeaways

This study is testing if semaglutide (Ozempic) helps heal diabetic foot ulcers.
It compares semaglutide plus standard care against standard care alone.
The main goal is to see how quickly ulcers close.
Researchers will also look at ulcer size, blood flow, and complications.
Adults aged 18 and over with a diabetic foot ulcer can participate.

Who may be eligible?

To join this study, participants need to be at least 18 years old – there's no upper age limit, so adults of all ages can be considered. Both men and women are welcome to take part in this research.

The most important requirement is that you have a diabetic foot ulcer. This study is specifically designed for people living with this condition to see if the new treatment can help them.

It's important to remember that the research team will check all your health details very carefully to make sure the study is safe and right for you. They will explain everything clearly during the screening process.

Quick self-check

Are you 18 years old or older?
Do you have a diabetic foot ulcer?
Are you male or female?
Are you able to attend regular appointments for check-ups?

This is a guide only — the research team will confirm whether you can take part.

What does participation involve?

If you decide to take part in this study, you would receive either different doses of Semaglutide (Ozempic) as an injection, or continue with your standard care for your diabetic foot ulcer. You would have regular visits to an outpatient clinic where the research team would measure your ulcer's size and depth. They would also take other measurements related to your leg, like blood pressure in your ankle and toe, both at the start and at regular intervals throughout the study. This will help them track your a progress. The total duration of your involvement could be up to 6 months of follow-up after your wound closes.

Potential risks and benefits

Taking part in a study means you might receive a new treatment that could potentially help your diabetic foot ulcer heal faster or reduce complications. However, as with any medicine, semaglutide can have side effects, and some people might not benefit from it. The research team will monitor you closely for any issues, and you'll be told about all known risks before you decide to join. Remember, participation is always voluntary, and you have the right to withdraw from the study at any time, for any reason, without it affecting your usual medical care.

Locations (1)

—
Netherlands

Common questions

What is a diabetic foot ulcer?

It's an open sore or wound on the foot that can affect people with diabetes, often due to nerve damage and poor circulation.

What is semaglutide (Ozempic)?

Semaglutide is a medicine, often known as Ozempic, that is currently used to treat type 2 diabetes. This study wants to see if it can also help heal foot ulcers.

Will I definitely get the study medication?

You might receive semaglutide in different doses, or you might be in a group that only gets standard care. The doctor leading the study will explain this.

How long will I be in the study?

The study will track your progress until your wound heals, or for up to 6 months after healing, whichever comes first, with regular check-ups.

Can I stop participating if I want to?

Yes, joining is completely your choice, and you can leave the study at any time without having to give a reason, and it won't affect your medical care.