Safety and Efficacy Trial of Epcoritamab Combinations in Subjects With B-cell Non-Hodgkin Lymphoma (B-NHL)

To join this study, people generally need to be 18 years or older and have a confirmed diagnosis of B-cell non-Hodgkin lymphoma, specifically Diffuse Large B-Cell Lymphoma or Follicular Lymphoma. Doctors will check scanned images (like CT or MRI) to ensure there is enough cancer to measure. Your overall health and how well your body's organs are working will also be checked, and you would need to be reasonably fit and able to carry out daily activities.

There are specific rules for each treatment group within the study. For example, some groups are for people who have just been diagnosed, while others are for those whose cancer has come back or hasn't responded to previous treatments. It’s important that your cancer cells also show a specific marker called CD20, as epcoritamab targets this.

Some things would prevent you from joining the study. For instance, if you've had certain cancer treatments (like chemotherapy or radiation) or major surgery very recently (within the last 4 weeks), or if you've previously had a specific type of treatment called a bispecific antibody that targets CD3 and CD20, or CAR-T therapy. If you are a woman who could become pregnant, or a man with a partner who could become pregnant, you would need to agree to use effective birth control during the study.

If you join this study, the duration of your treatment will depend on which specific treatment group you are assigned to. For all participants, visits to the clinic will be weekly at the beginning. As treatment continues, these visits will become less frequent, potentially every 2, 3, 4, or even 8 weeks, depending on your treatment group.

Everyone in the study will receive the active study medicine, epcoritamab, which is given as an injection just under the skin. The exact way you receive epcoritamab (how much and how often) will vary depending on your assigned treatment group. If your treatment group combines epcoritamab with other standard cancer medicines, these might be given into a vein (like a drip) or as tablets, again depending on your specific group.

During your visits, you will have various assessments to check your health, how the treatment is working, and to monitor for any side effects. These could include blood tests, scans, and physical examinations.