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Not yet recruitingNAINTERVENTIONAL

Study of Blinking as a Function of Tear Film Quality

This study aims to understand the link between how we blink and the quality of our tears. Researchers want to find out if the way people blink is different for those with dry eyes compared to those who don't have them. They will be studying adults aged 18 to 65. Participants will complete questionnaires, have their vision checked, and undergo non-invasive eye scans to measure tear film quality. They will also do different blinking activities while measurements are taken. The goal is to see if new ways of measuring blinks can tell us about tear film quality and how these measures relate to each other in people with and without dry eye symptoms.

At a glance

Status
Not yet recruiting
Phase
NA
Sponsor
Essilor International
Enrolment target
60
Start
01 Mar 2026
Estimated completion
01 Jun 2026

What is this study about?

This study is about understanding something we do all the time without thinking: blinking! Blinking is really important because it spreads a thin layer of liquid, called the tear film, across your eye. This tear film keeps your eyes comfortable, moist, and helps you see clearly. If your tear film isn't stable, it can lead to dry eye discomfort.

The researchers in this study want to find out how the way people blink connects to how stable their tear film is. They're especially interested in whether different blinking patterns are seen in people who experience dry eye symptoms compared to those who don't. By looking closely at how people blink and how their tear film behaves, they hope to learn more about dry eye and potentially develop better ways to help people who suffer from it.

To do this, they'll be asking adults between 18 and 65 years old to take part. Some participants will have dry eye symptoms, and others won't. This will allow the researchers to compare the two groups. It's a non-invasive study, meaning no needles or surgery, and focuses on observing natural eye functions.

Key takeaways

  • This study explores the link between blinking and tear film quality.
  • It compares people with and without dry eye symptoms.
  • Participation involves questionnaires and non-invasive eye tests.
  • The study aims to improve our understanding of dry eye.
  • It helps contribute to future potential treatments for dry eye.

Who may be eligible?

To join this study, you need to be between 18 and 65 years old. You should be able to speak and understand French, as you'll need to read and consent to the study information. It's also important that you have routine social security coverage.

There are some reasons why you might not be able to participate. For example, if you work for certain eye care companies like Essilor, Luxottica, or GrandVision, you can't join. If you are pregnant or breastfeeding, or if you've recently used eye drops (within 2 hours) or worn contact lenses (within 48 hours), you won't be able to take part. Also, if you have certain eye conditions beyond dry eye, or have had recent eye surgery (except for laser eye surgery or cataract removal), or issues with your eyelids, you might not be eligible.

Finally, if you have serious health problems that affect your balance or movement, or if you're already taking part in another study and are in a period where you can't join new ones, you would not be able to participate. The study team will make the final decision to ensure everyone's safety and that the study is run properly.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

  1. Are you between 18 and 65 years old?
  2. Can you read and understand French?
  3. Have you avoided eye drops for the last 2 hours and contact lenses for the last 48 hours?
  4. Are you generally in good health with no major eye conditions (other than dry eye) or recent eye surgeries (except for laser eye surgery or cataract removal)?
  5. Are you not pregnant or breastfeeding?
Answer every question to see your result.

What does participation involve?

If you decide to take part in this study, you will first need to read and understand the study information and give your consent. You'll then be asked to fill out a questionnaire about any dry eye symptoms you might have. Your vision will be checked, especially if you wear glasses.

Next, you'll have your tear film quality measured using a special imaging device. This is a non-invasive process, meaning nothing touches your eye. You'll also be asked to perform three different blinking tasks, each repeated three times. During these tasks, researchers will measure your blinking patterns and tear film stability. The study involves a single visit, and the total duration in the study is just the time you spend during that visit.

Potential risks and benefits

Taking part in this study could help scientists learn more about dry eye, which might lead to better ways to understand and help people with this condition in the future. While there's no direct personal benefit from taking part, contributing to medical knowledge is valuable. The risks involved are very low, as the assessments are non-invasive and generally comfortable; you might experience a bit of eye strain from the blinking tasks. Remember, you can choose to leave the study at any time, for any reason, without it affecting your medical care.

Locations (1)

  • EssilorLuxottica - Neuroscience & Medical Research center
    Verified postcode
    Paris, France

Common questions

What is 'tear film stability'?

Tear film stability means how long the tear layer on your eye stays smooth and complete before it starts to break up.

Will I get medication in this study?

No, this study does not involve giving any medication. It's an observational study focusing on blinking and tear film.

How long will my participation take?

Your participation will involve a single visit to complete all the tasks and measurements.

Do I need to stop using my regular eye drops?

You will need to avoid using eye drops or similar solutions for at least 2 hours before your study visit.

Is there any cost to me for participating?

No, there is no cost to you for participating in this research study.

How to find out more

Sarah Marié, MSc

Always speak to your GP or specialist before deciding to take part in a study.

Interested in taking part?

Register your interest

Share your details and the research team for "Study of Blinking as a Function of Tear Film Quality…" will contact you if you may be eligible. Always speak to your GP before agreeing to take part.

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