RecruitingOBSERVATIONAL

Prevalence and Description of FIRE (Food Induced Immediate Response of the Esophagus) in the Pediatric Population With Eosinophilic Esophagitis

This study is investigating a recently identified condition called FIRE (Food Induced Immediate Response of the Esophagus) that affects children and teenagers who also have eosinophilic esophagitis, a type of allergy in the food pipe. Since FIRE was only described in 2020, doctors are still learning about it and how to properly diagnose it. This research aims to gather information on how common FIRE is and to describe its characteristics in young people. By understanding FIRE better, doctors hope to distinguish it from other similar conditions like allergies in the mouth or throat, or blockages caused by the food pipe inflammation itself. The goal is to collect important details to help with future diagnosis and treatment.

At a glance

Status

Recruiting

Sponsor

University Hospital, Angers

Enrolment target

Start

01 Jul 2025

Estimated completion

01 May 2026

Eosinophilic Esophagitis

What is this study about?

This study is looking into a newly recognised condition called FIRE, which stands for Food Induced Immediate Response of the Esophagus. The 'esophagus' is another name for your food pipe. FIRE has been observed in children and teenagers who suffer from eosinophilic esophagitis, which is an allergic reaction in the food pipe that can make it difficult or painful to swallow.

Because FIRE was only first described in 2020, doctors are still learning a lot about it. They don't yet have clear rules for how to diagnose it. They also want to understand how it's different from other conditions that might have similar symptoms, such as allergic reactions in the mouth and throat, or a physical blockage caused by the inflammation in the food pipe itself.

The main aim of this research is to collect information on how many young people with eosinophilic esophagitis also experience FIRE. By doing this, the researchers hope to get a clearer picture of this condition, including its symptoms and how often it occurs. This will help doctors better understand and potentially treat FIRE in the future.

Key takeaways

This study focuses on a new condition called FIRE.
It aims to understand FIRE in young people with eosinophilic esophagitis.
Participation involves answering questions about your symptoms.
No new medications or treatments are given in this study.
The goal is to help doctors better understand and diagnose FIRE.
You must be 6 to 17 years old and already receiving care at a specific hospital.

Who may be eligible?

This study is looking for children and teenagers aged between 6 and 17 years old. You must be at least 6 years old but not yet 18 when you join the study.

Another important requirement is that you must already be receiving care for eosinophilic esophagitis at the allergology unit at Angers University Hospital in France.

However, if you or your parent/guardian have severe difficulties understanding or speaking, or if you or your parent/guardian do not want to take part, then you won't be able to join the study.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you between 6 and 17 years old?
Do you have eosinophilic esophagitis?
Are you currently being treated for your condition at Angers University Hospital?
Can you understand and communicate easily about your health?
Are you or your parent/guardian happy to take part in the study?

Answer every question to see your result.

What does participation involve?

The study aims to gather information about FIRE. This largely involves answering specific questions about your experiences and symptoms with your condition. You won't be given any new medications or treatments as part of this particular study. The information collected will help doctors understand more about FIRE. The total duration of your involvement will depend on the standard follow-up schedule you already have for your eosinophilic esophagitis.

Potential risks and benefits

Taking part in this study is generally considered low risk, as it mainly involves answering questions about your existing condition and receiving your usual care. There are no new treatments or medications involved. A potential benefit is that contributing your experiences could help doctors understand FIRE better, which might lead to improved diagnosis and care for other young people in the future. You always have the right to withdraw from the study at any time, for any reason, without it affecting your medical care.

Locations (2)

HOPPE Anne
Verified postcode
Angers, France· Recruiting
CHU Lille
Verified postcode
Lille, France· Not yet recruiting

Common questions

What is eosinophilic esophagitis?

It's an allergic condition where a specific type of white blood cell (eosinophils) build up in the food pipe, causing inflammation and making it hard to swallow.

What does FIRE stand for?

FIRE stands for Food Induced Immediate Response of the Esophagus.

Will I receive new medicine in this study?

No, this study does not involve giving you any new medicines or treatments. It's focused on understanding existing conditions.

Why are doctors studying FIRE now?

FIRE is a new condition, only recognised in 2020. Doctors want to learn more about how common it is and what its symptoms are to help patients in the future.

How long will I be in the study?

Your involvement in the study will be linked to your existing follow-up appointments for your eosinophilic esophagitis.

How to find out more

Anne HOPPE, MD

anne.hoppe@chu-angers.fr 241353637 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.