A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Episodic Migraine

To join this study, you need to have been diagnosed with episodic migraine for at least a year and be able to tell the difference between a migraine and other headaches. Your migraines should have started before you were 50 years old. In the three months before the study starts, you should have had no more than 14 headache days in total each month, and specifically between 6 and 14 migraine days per month. These numbers will also be checked during the last month of the initial screening period.

There are also some reasons why you wouldn't be able to join. For example, if you have chronic migraine (migraines very frequently), or other specific types of headache like 'migraine with brainstem aura' or 'hemiplegic migraine', you wouldn't be eligible. Also, if you're currently taking more than one medication specifically to prevent migraines, or if you recently stopped a particular type of migraine prevention treatment (CGRP inhibitors) within the last five months, you wouldn't be able to participate. Having a headache due to overusing medication is usually okay, as is having tension headaches.

If you decide to take part, the study will last between 52 and 55 weeks, which is about a year. It starts with a screening period of about 4 to 5 weeks to make sure you meet all the requirements.

During the main part of the study, you'll receive injections four times, with each set of injections about 12 weeks apart. You'll have a total of 14 visits throughout the year. The first visit, the last visit, and the four visits where you get injections will be in person at the clinic. The other eight visits will be done remotely, meaning you can speak to the study team over the phone or by video call, usually every four weeks.