Closed-loop TMS for Tremor
This research is exploring a new way to help people who experience tremors due to Essential Tremor or Parkinson's Disease. It uses a non-invasive technique called Transcranial Magnetic Stimulation (TMS). Imagine trying to calm a swing by pushing it at the right moment – TMS aims to do something similar with brain activity linked to tremors. We hope to see if precisely timed TMS can reduce the shaking. Current treatments sometimes have side effects or aren't effective for everyone, so we're looking for a gentler option. This study will check if TMS can quickly lessen tremors and how effective different timing of the stimulation might be. It's about finding a potential new way to improve quality of life.
At a glance
What is this study about?
Many people live with tremors, which are uncontrollable shakes that can make everyday tasks challenging. Two common conditions causing tremors are Essential Tremor and Parkinson's Disease. While there are treatments available, they don't always work for everyone, can have side effects, or involve surgery. Because of this, scientists are always looking for new, gentler ways to help.
This study focuses on a technique called Transcranial Magnetic Stimulation (TMS). It's a non-invasive procedure, meaning it doesn't involve surgery or needles. Instead, a device held near the head creates a magnetic field that delivers very mild electrical pulses to a specific part of the brain. The idea behind this study is similar to pushing a swing: if you push it at just the right moment, you can either make it go higher or slow it down. We believe that by timing these TMS pulses precisely with a person's tremor, we might be able to calm the brain activity that causes the shaking.
The research has two main parts. First, we want to see if this specially timed (phase-locked) TMS can immediately reduce tremor. Then, we'll investigate if stimulating at the very best moment in the tremor cycle works better than stimulating at other times or not stimulating at all. Our goal is to see if this method could be a new, less invasive treatment option for people living with tremors, potentially offering relief without the risks or limitations of existing therapies.
Key takeaways
- This study explores a non-invasive brain stimulation (TMS) for tremors.
- It targets tremors in Essential Tremor and Parkinson's Disease.
- The goal is to reduce shaking by timing mild pulses perfectly with your tremor.
- Participation involves a few short visits for tremor measurement and TMS sessions.
- It aims to find a new, potentially gentler treatment option.
- There's no guarantee of personal benefit, but findings could help others in the future.
Who may be eligible?
To join this study, you need to be at least 18 years old and have a diagnosed tremor due to either Essential Tremor or Parkinson's Disease. You also need to be able to understand the study and agree to take part.
There are certain reasons why someone might not be able to join. These include having any medical condition or device that makes brain stimulation unsafe, such as a pacemaker, metal implants in your head, or a history of seizures or certain mental health conditions. If you're unsure if you qualify, it's best to discuss it with your doctor.
Could this study suit you?
Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.
- Are you at least 18 years old?
- Do you have a diagnosis of Essential Tremor or Parkinson's Disease with tremors?
- Do you have any metal implants in your head or a pacemaker?
- Do you have a history of epilepsy or seizures?
- Are you able to understand the study and give your consent to take part?
What does participation involve?
If you decide to take part, you'll have a few visits to our research centre. During these visits, we'll measure your tremor using small sensors placed on your body (like smartwatches) and sometimes electrodes on your skin. These measurements help us understand how your tremor changes. We will then use the TMS device, which is a coil placed gently on your head, to deliver brief, targeted pulses to your brain while we continue to record your tremor.
Each study session will last less than two hours. You might need to stop taking some of your tremor medications for a short time before and during your visits, but this will always be discussed with you and your doctor. You'll complete a few questionnaires to tell us about your tremor and how it affects your daily life. You are free to withdraw from the study at any time without any penalty.
Potential risks and benefits
Locations (1)
- Oxford Center for Integrative NeuroimagingVerified postcodeOxford, United Kingdom· Recruiting
Common questions
What is TMS?
TMS stands for Transcranial Magnetic Stimulation. It's a gentle, non-invasive way to stimulate specific parts of the brain using magnetic pulses through a device held near the head.
Is TMS painful?
Most people find TMS comfortable, though you might feel a tapping sensation on your scalp. Some mild, temporary side effects like headaches can occur, similar to a light tap on the head.
How long will the study visits take?
Each visit to the study centre is expected to last less than two hours, including time for setting up and recording measurements.
Do I have to stop my tremor medication?
You might be asked to temporarily hold back on some tremor medications before or during visits. This will be discussed fully with you and your own doctor to ensure your safety and comfort.
What if I change my mind about participating?
You are free to stop participating in the study at any time, for any reason, without having to explain why, and it will not affect your medical care.
How to find out more
Charlotte Stagg J Professor of Human Neurophysiology, MBBS
Always speak to your GP or specialist before deciding to take part in a study.
Interested in taking part?
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