RecruitingOBSERVATIONAL

Engagement Study for Participants With Factor V Leiden and Prothrombin G20210A Mutations

This study is looking for people who have, or might have, specific genetic changes called Factor V Leiden or Prothrombin G20210A. These changes can mean you have a higher chance of developing blood clots. The aim is to confirm if you have these genetic changes through a special test. If confirmed, you'll have some basic health checks like blood pressure and blood tests. This helps doctors understand your health better and see if you might be suitable for future studies related to blood clots. It also gives you a chance to see how clinical trials work and meet the team, helping you understand what's involved before deciding on future participation. The study lasts about 10 weeks, with one or two visits and a phone call.

At a glance

Status

Recruiting

Sponsor

Richmond Research Institute

Enrolment target

100

Start

21 Apr 2026

Estimated completion

31 Jan 2027

Factor V Leiden Prothrombin G20210A

What is this study about?

This study is designed for individuals who either have, or think they might have, two specific genetic changes: Factor V Leiden or Prothrombin G20210A. Think of genetic changes as tiny, natural differences in your body's instruction manual. For some people, these particular changes can mean they have a slightly higher chance of developing blood clots. This study isn't about giving you new medicines or treatments; instead, it's an important first step to help us understand more about these conditions and the people who live with them.

One of the main goals is to confirm if you indeed have one of these genetic changes through a simple test. For some people, this could be the first time they receive a formal diagnosis, which can be very helpful. Once confirmed, you'll have some basic health checks – things like measuring your blood pressure, taking a heart recording (ECG), and having some blood tests. These checks help doctors get a good picture of your general health and create a 'baseline' understanding.

Crucially, this study also offers you a unique opportunity to learn about clinical research. You'll get to visit the clinic where trials happen and meet the healthcare team. This helps you understand what it's like to take part in a study before you ever consider joining a future one that might be testing new treatments for blood clot conditions. It's all about making sure you feel comfortable, informed, and confident if you choose to get involved in research later on.

Key takeaways

Learn if you have specific genetic changes linked to blood clots.
Understand what it's like to take part in medical research.
Help doctors learn more about these genetic conditions.
Participation involves 1-2 visits and a phone call over 10 weeks.
No medication or new treatments are given in this study.

Who may be eligible?

This study is open to anyone aged 18 or over. You need to be able to understand the study information and give your written consent to take part. It's important that you or your doctor suspect you might have Factor V Leiden or Prothrombin G20210A genetic changes, or that you've already been diagnosed with them.

You cannot take part if you are unwilling or unable to follow the study instructions, or if you have any other significant health condition that the study doctor thinks could make it unsafe for you to participate, or affect the results.

Essentially, we're looking for adults who are interested in learning more about their potential genetic predisposition to blood clots and understanding clinical research.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Can you read and understand information about the study and give written permission to take part?
Do you or your doctor suspect you might have Factor V Leiden or Prothrombin G20210A, or do you already know you have one?
Are you able to attend appointments and follow study instructions?

Answer every question to see your result.

What does participation involve?

If you decide to join, the study will last for about 10 weeks. Your first step will be a 'screening visit' where the study will be fully explained, and you'll have the chance to ask any questions. If you then agree, you'll provide written consent. For those who are suspected of having one of the genetic changes, a genetic test will be done.

If the genetic test confirms you have Factor V Leiden or Prothrombin G20210A, you'll be invited for a second visit. During this visit, you'll have some basic health checks, including blood pressure measurements, a heart recording (ECG), and blood tests. You'll also get a tour of the clinic and meet the team. After these visits, there will be a follow-up telephone call. You won't be given any medication as part of this particular study, nor will there be regular ongoing treatments.

Potential risks and benefits

A potential benefit of joining this study is finding out if you have one of these specific genetic changes, which could be an important health insight. You'll also learn first-hand what it's like to be part of a clinical trial, helping you make informed decisions about any future opportunities. The main risks are minor discomfort from blood tests, similar to any routine blood draw, and the time commitment for visits. You are free to withdraw from the study at any time, for any reason, without it affecting your medical care.

Locations (1)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

Richmond Pharmacology Limited
Verified postcode
London, United Kingdom· Recruiting

Common questions

What are Factor V Leiden and Prothrombin G20210A?

These are genetic changes that can make your blood more likely to form clots.

Do I need to already know if I have these conditions to join?

No, you can join if you or your doctor suspect you might have them; the study can help confirm this.

Will I receive any new treatment in this study?

No, this study is about understanding your health and introducing you to clinical research, not testing treatments.

How long will I be involved in the study?

The study lasts about 10 weeks in total, with one or two visits to the clinic and a follow-up phone call.

Will I get paid for taking part?

The information provided does not mention payment, but you should ask the study team about any reimbursement for travel expenses.

How to find out more

James Rickard, MPharm

jrickard@richmondresearchinstitute.org +44 (0) 20 7042 5800 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.