AuthorisedTherapeutic exploratory (Phase II)Interventional

Diagnostic Efficacy of 18F-FAPI-74 PET/CT in Patients with Gastric Cancer

This study is investigating a new scanning method called 18F-FAPI-74 PET/CT for patients diagnosed with stomach cancer. The main goal is to find out how accurately this special scan can detect the original tumour, any cancer cells that have spread to nearby lymph nodes, and if the cancer has spread to other parts of the body. This information is really important for doctors to plan the best treatment. We will compare the results of these scans with standard tests, like looking at tissue under a microscope, or other scans over time, to understand how well the new scan works. Understanding how cancer has spread is key to making sure patients get the most effective care.

At a glance

Status

Authorised

Phase

Therapeutic exploratory (Phase II)

Sponsor

Varsinais-Suomen hyvinvointialue

Enrolment target

Start

05 Jun 2026

Gastric cancer

What is this study about?

This research is looking into a new type of scan called 18F-FAPI-74 PET/CT. It's for people who have stomach (gastric) cancer. You might already know that doctors use different scans to understand cancer, but this study wants to see if this new scan can give doctors even clearer pictures and more detailed information.

The main aim is to check how good this new scan is at finding the main cancer lump in the stomach, any cancer cells that might have spread to lymph nodes (small glands that are part of your body's defence system), and if the cancer has spread to other parts of the body. Knowing exactly where the cancer is and if it has spread is crucial for doctors to decide on the best treatment plan for each person.

To see how well this new scan works, the results will be compared with other methods doctors already use. This includes looking at tissue samples under a microscope (which is often called the 'gold standard' because it's very reliable) or comparing with regular scans and follow-up checks over a year. By doing this, we can learn if the 18F-FAPI-74 PET/CT scan could become a valuable tool in the future for diagnosing and managing stomach cancer.

Key takeaways

This study is testing a new type of scan for stomach cancer.
It aims to find out how well the scan detects cancer and its spread.
The scan uses a special substance called 18F-FAPI-74.
It's open to adults aged 18 and over with stomach cancer.
The goal is to improve how doctors understand and manage stomach cancer.

Who may be eligible?

This study is open to both men and women.

You must be at least 18 years old to take part. There is no upper age limit, meaning older adults are also welcome to participate.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Do you have stomach cancer?
Are you 18 years old or older?
Are you able to attend appointments for scans and check-ups?
Are you comfortable with having a new type of scan?

Answer every question to see your result.

What does participation involve?

The information provided doesn't give specific details on what taking part involves, such as the number of visits, how long each visit might be, or the total duration of your involvement in the study. However, because it's a study looking at a new type of scan, it's very likely that participation would involve at least one 18F-FAPI-74 PET/CT scan. You might also have other tests, like blood samples or standard exams, so doctors can compare results.

There would also be follow-up appointments, potentially including more scans or check-ups, to see how the cancer is progressing and how the new scan's results compare with your longer-term health. The study mentions comparing scan findings to routine clinical follow-up for up to a year, suggesting some level of follow-up over that period.

Potential risks and benefits

Taking part in any study has potential benefits and risks. A potential benefit of this study is that it might help doctors better understand your cancer through the new scan, which could lead to more tailored treatment in the future, possibly for you or for others. The study is also helping to advance medical knowledge, which benefits everyone. However, as 18F-FAPI-74 is a new substance, there might be unknown side effects, though it will have been carefully tested before being used in this phase of the study. You will be exposed to a small amount of radiation from the PET/CT scan, similar to other medical scans. You always have the right to withdraw from the study at any time, for any reason, without it affecting your usual medical care.

Locations (1)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

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Unverified
Finland

Common questions

What is 18F-FAPI-74 PET/CT?

It's a new kind of medical scan that uses a special substance (18F-FAPI-74) to help doctors see stomach cancer more clearly.

Why is this study being done?

The study aims to see if this new scan is better at finding stomach cancer, including if it has spread, compared to current methods.

Who can join this study?

Anyone aged 18 or over, male or female, who has stomach cancer.

Will I get special treatment if I join?

The study focuses on the diagnostic scan. It aims to improve how stomach cancer is understood, which could lead to better treatment plans in the future, but it doesn't offer a new treatment itself in this phase.

Is the scan safe?

Like all scans involving radiation, there's a small exposure to radiation. The new substance used will have been tested for safety, but potential side effects will be discussed fully.