AuthorisedTherapeutic use (Phase IV)Interventional

Rapid sequence emergence of general Anaesthesia

This study is investigating how quickly patients recover from general anaesthesia. When you have an operation under general anaesthetic, doctors give you medicines to make you sleep and relax your muscles. This study is testing different medicines that can help you wake up and start breathing on your own again after the operation. Researchers want to find out which medicines work best and fastest to help you recover your natural breathing, open your eyes, and become fully awake. They are also looking at your blood pressure, heart rate, and other body functions during this recovery period, as well as how satisfied your doctors are with the recovery process. This is important for making anaesthesia recovery as smooth and safe as possible.

At a glance

Status

Authorised

Phase

Therapeutic use (Phase IV)

Sponsor

Stichting Radboud universitair medisch centrum

Enrolment target

Start

02 Dec 2025

General anesthesia

What is this study about?

Imagine you're having an operation and need to be completely asleep. To do this, doctors give you special medicines called general anaesthetics. These medicines also relax your muscles so you don't move during surgery. When the operation is over, it's really important for you to wake up safely and quickly, and for your breathing to return to normal.

This study is looking at this very important stage, called 'emergence' from anaesthesia. Researchers are testing different medicines that can help reverse the effects of the anaesthetic and muscle relaxants. They want to find out how quickly people start breathing on their own again, how soon they open their eyes, and if they can swallow or cough. They'll also be keeping a close eye on other important things like your heart rate and blood pressure to make sure everything is stable.

The main goal of this study is to discover the best ways to help people wake up gently and quickly after surgery. By understanding how these different medicines work, doctors can choose the safest and most effective options for patients, leading to a smoother and faster recovery from general anaesthesia.

Key takeaways

This study helps understand how best to wake people up after surgery.
It tests different medicines to speed up recovery from general anaesthesia.
The study looks at how quickly you can breathe on your own and become alert.
It's for adults having an operation under general anaesthesia.
Your recovery will be closely monitored by medical staff.
Participation is voluntary and won't affect your medical care.

Who may be eligible?

This study is open to adults aged 18 and over, with no upper age limit. Both men and women can take part.

More details about specific health conditions or medications you might be taking would be discussed with the study team. Generally, if you are planning to have an operation that requires general anaesthesia, you might be suitable for this study.

The study team will carefully review your medical history to make sure it's safe and appropriate for you to participate.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Are you planning to have an operation that requires general anaesthesia?
Are you able to understand and provide informed consent for the study?
Are you able to attend appointments for your scheduled operation?

Answer every question to see your result.

What does participation involve?

If you decide to take part in this study, the process will be integrated into your surgical experience. During your anaesthesia for an operation, you would be given one of the study medicines to help you wake up at the end. The study team would then carefully observe your recovery. This would involve monitoring how quickly you start breathing on your own, when you open your eyes, and when you can swallow or cough. They would also keep track of your heart rate, blood pressure, and how alert you become. All of these measurements would be standard monitoring for anyone recovering from anaesthesia, but in this study, they would be specifically recorded for research purposes. There would be no extra visits beyond your hospital stay for the operation itself, and involvement would cease once you have fully recovered from the anaesthetic in the recovery ward. The total duration of your active participation would be during and immediately after your surgery, usually lasting a few hours.

Potential risks and benefits

Taking part in this study might mean you recover from anaesthesia more quickly, which could potentially shorten your time in the recovery room. The medicines used are generally common medications that are already approved for use in hospitals. As with any medical procedure, there are always potential risks, such as unexpected reactions to medicines, but these are carefully managed by the medical team. You will be closely monitored throughout your recovery. You are free to withdraw from the study at any time without giving a reason, and this will not affect your medical care.

Locations (1)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

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Unverified
Netherlands

Common questions

What is 'general anaesthesia'?

General anaesthesia is when doctors give you medicines to make you completely asleep so you don't feel anything during an operation.

What does 'emergence' mean in this study?

Emergence means the process of waking up and recovering from the effects of general anaesthesia after your operation.

Will I know which medicine I'm getting?

The study team will explain how the medicines are chosen. Sometimes patients receive a specific medicine, and sometimes it's decided randomly, like tossing a coin.

Will this study affect my operation?

No, this study focuses on the recovery stage after your operation. Your surgical procedure will proceed as planned, and your safety is always the top priority.

Do I have to take part?

No, taking part is completely your choice. If you decide not to participate, it will not affect your medical care in any way.