RecruitingNAINTERVENTIONAL

oCular Examination at Cell RESolution With Optical TransmissionTomography

This study is looking at new ways to take pictures of the front of the eye to better understand eye conditions. Researchers are using a brand-new imaging method called Optical Transmission Tomography (OTT) alongside existing techniques like Optical Coherence Tomography (OCT) and Specular Microscopy (SM). The goal is to see if OTT can provide clearer, more detailed images, cover a wider area, and be quicker than current methods. This could help doctors diagnose and monitor eye diseases like glaucoma, cataracts, and problems with the cornea more effectively. The study includes both healthy volunteers and people with various eye conditions, comparing how these different imaging tools work.

At a glance

Status

Recruiting

Phase

Sponsor

Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts

Enrolment target

300

Start

12 Nov 2024

Estimated completion

12 Nov 2029

Glaucoma Associated With Other Ocular Disorders

What is this study about?

Imagine being able to see tiny details inside your eye that doctors can't currently see clearly. This study is all about improving how we take pictures of the front part of your eye, which includes important structures like the cornea (the clear front window), the lens (which focuses light), and the area linked to glaucoma.

Currently, doctors use imaging tools like OCT, but sometimes these don't show enough detail or take too long. Our research team has helped develop a new type of imaging called Optical Transmission Tomography (OTT). This new method promises to take very detailed pictures, covering a wider area of the eye, and might even be quicker.

By comparing this new OTT technology with existing methods like OCT and Specular Microscopy, we hope to find a better way to understand and track eye diseases. This could lead to earlier diagnosis and more personalised care for conditions like glaucoma, cataracts, and other problems affecting the front of the eye.

Key takeaways

Researchers are testing a new eye imaging method (OTT).
It aims for clearer, faster scans of the eye's front part.
Compares new tech with existing methods (OCT, SM).
Includes healthy volunteers and patients with eye conditions like glaucoma or cataracts.
Participation involves eye scans over 2-4 years.
Open to adults aged 18-80 covered by French health insurance.

Who may be eligible?

This study is looking for two groups of people: healthy volunteers and patients with certain eye conditions.

For patients, you might be able to join if you are between 18 and 80 years old, male or female, and have an eye condition affecting your cornea, eye surface, lens (like a cataract), or glaucoma. You might also be eligible if you're having or have recently had refractive eye surgery. Importantly, you need to be covered by the French health insurance system (Assurance Maladie) and be able to give your informed consent.

For healthy volunteers, you would need to be between 18 and 80 years old, male or female, with healthy eyes (no known eye conditions). Like the patient group, you'd need to be covered by French health insurance and provide informed consent.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you between 18 and 80 years old?
Are you covered by the French health insurance system?
Can you hold your head still on an eye rest for a short time?
Do you have a specific eye condition (e.g., glaucoma, cataract) or are your eyes healthy?
Do you not have an implanted electronic medical device?
Are you not pregnant or breastfeeding?

Answer every question to see your result.

What does participation involve?

If you decide to take part, you will have your eyes imaged using all three scanning systems: OTT, OCT, and Specular Microscopy. These scans are done during your visits.

If you are a healthy volunteer, you'll have two sets of imaging examinations: one at the start of the study and another two years later. Two different people will operate the scanning machines during these sessions, and several images will be taken.

If you are a patient, you'll have these imaging examinations at your initial visit and then at follow-up appointments, which will depend on your eye condition and usual hospital schedule. Your participation could last up to four years, with images taken by two different operators at each visit.

Potential risks and benefits

Taking part could help scientists learn more about eye diseases, potentially leading to better future treatments and understanding. The imaging procedures are generally safe and non-invasive, meaning no surgical procedures are involved. However, you will need to hold your head still for a period during the scans, which might be uncomfortable for some. There is also a very small chance of eye irritation during the examination. You are free to withdraw from the study at any time, for any reason, without it affecting your medical care.

Locations (1)

Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
Verified postcode
Paris, France· Recruiting

Common questions

What is OTT?

OTT (Optical Transmission Tomography) is a new eye scanning technology designed to take very detailed and wide-ranging pictures of the front part of your eye, like the cornea and lens.

Will I get paid for taking part?

The information provided does not mention any payment for participation.

What if I have an electronic device like a pacemaker?

If you have an implanted pacemaker or similar electronic medical device, you would not be able to participate in this study.

How long will the study last for me?

If you are a healthy volunteer, you will have two visits over two years. If you are a patient, your participation could last up to four years, depending on your eye condition and follow-up schedule.

Do I need to live in France to participate?

Yes, you must be covered by the French health insurance system (Assurance Maladie) to be eligible for this study.

How to find out more

Nabil BROUK

nbrouk@15-20.fr 00 33 1 40 02 11 44 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.