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RecruitingNAINTERVENTIONAL

Assessing the Impact of a Leucine Enriched Whey Protein vs Isonitrogenous Whey on Muscle Protein Synthetic Responses in the Rested and Acute Post Exercise States in Older Adults

This study focuses on men over 65 and how their muscles respond to protein supplements. As people get older, their muscles can become less responsive to protein and exercise, making it harder to maintain muscle mass. This is often called 'anabolic resistance'. We are investigating whether a special type of whey protein, enriched with an important amino acid called leucine, can help overcome this. We'll compare it to a standard whey protein to see if the enriched version is better at stimulating muscle growth and repair. This research aims to understand how to best support muscle health in older adults to help prevent weakness and improve overall well-being.

At a glance

Status
Recruiting
Phase
NA
Sponsor
University of Nottingham
Enrolment target
30
Start
14 Mar 2025
Estimated completion
28 Feb 2029

What is this study about?

As we get older, keeping our muscles strong and healthy becomes increasingly important. Our muscles do a lot for us – they help us move, support our body, and even play a role in our overall health. However, with age, muscles can sometimes become less responsive to things like exercise and eating protein, which usually help them grow and repair. This can lead to a gradual loss of muscle mass and strength, a condition sometimes called sarcopenia. It can make everyday activities harder and increase the risk of falls.

Protein is vital for muscle health. When we eat protein, our body breaks it down into smaller building blocks called amino acids, which our muscles then use to repair and grow. One particular amino acid, called leucine, seems to be especially good at kick-starting this process in muscles. Our bodies can't make leucine, so we need to get it from our diet.

In this study, we want to find out if a special type of whey protein, which has extra leucine added, can help older men's muscles respond better. We'll compare it to a regular whey protein to see if the enriched version is more effective at stimulating muscle repair and growth, both when someone is resting and after they've done some exercise. We hope this research will provide valuable information to help older adults maintain their muscle health and stay active.

Key takeaways

  • The study focuses on men aged 65 and over.
  • It aims to improve muscle health in older adults.
  • It compares two types of whey protein: one with extra leucine, one without.
  • Researchers will look at muscle response both when resting and after exercise.
  • The goal is to understand how to best support muscle strength and function as we age.

Who may be eligible?

This study is looking for healthy men who are aged 65 or older. You should be generally well and not have any serious health conditions that could affect the study results, especially those related to your heart, brain, lungs, or metabolism.

There are certain reasons why you wouldn't be able to take part. For example, if you are very overweight or underweight (with a BMI outside 18-35 kg/m2), or have conditions like uncontrolled high blood pressure, angina, or severe lung disease. We also can't include you if you have certain blood clotting issues, neurological conditions like epilepsy, muscle conditions, or if you're lactose intolerant.

Finally, if you've recently participated in another research study that involved medical procedures or a payment within the last three months, you wouldn't be eligible for this particular study.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

  1. Are you a man aged 65 or older?
  2. Do you feel generally healthy with no major ongoing medical conditions (like severe heart or lung disease)?
  3. Are you not severely overweight or underweight (BMI between 18 and 35)?
  4. Are you able to consume dairy products, meaning you're not lactose intolerant?
  5. Have you not taken part in another research study involving medical procedures in the last 3 months?
Answer every question to see your result.

What does participation involve?

The information provided does not detail what taking part involves. Typically, such studies require a screening visit, several study visits where you would consume the protein supplements, and have blood or muscle samples taken. There would also likely be exercise sessions. The total duration of your participation would be confirmed by the research team.

Potential risks and benefits

Participating in this study might offer the benefit of contributing to our understanding of how to maintain muscle health in older age, which could help many people in the future. While protein supplements are generally safe, there could be minor risks associated with blood tests or muscle biopsies, such as bruising or discomfort. All procedures would be explained fully, and you would have the right to withdraw from the study at any time without giving a reason.

Locations (1)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.
  • Royal Derby Hospital Medical School
    Verified postcode
    Derby, United Kingdom· Recruiting

Common questions

What is 'whey protein'?

Whey protein is a common protein found in milk, often used as a supplement to help with muscle repair and growth.

What is 'leucine'?

Leucine is a specific building block of protein (an amino acid) that is thought to be particularly important for stimulating muscle growth.

Why is this research important for older adults?

As we age, our muscles can become weaker. This study aims to find better ways to help older adults maintain strong, healthy muscles.

Will I have to exercise in this study?

The study looks at muscle response both at rest and after exercise, so it is likely that some exercise will be involved.

What does 'anabolic resistance' mean?

It means that older muscles might not respond as strongly to protein and exercise as younger muscles, making it harder for them to grow or repair.

How to find out more

Jake Cox

Always speak to your GP or specialist before deciding to take part in a study.

Interested in taking part?

Register your interest

Share your details and the research team for "Assessing the Impact of a Leucine Enriched Whey Protein vs I…" will contact you if you may be eligible. Always speak to your GP before agreeing to take part.

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